May. 10, 08:25:17 2013 [ Text modified to reflect that this was run under PSVS - Aneerban Bhattacharya: Dec 2005 ] The following checks were made on : ----------------------------------------- CLOSE CONTACTS ==> Distances smaller than 2.2 Angstroms are considered as close contacts for heavy atoms, 1.6 Angstroms for hydrogens. Chain Atom Res Seq Chain Atom Res Seq Mol_ID Distance ------------------------------------------------------------------------- A HA SER 55 - A HE1 TYR 58 19 Dist = 1.45 A HA LEU 12 - A HE2 TYR 73 17 Dist = 1.49 A HA ASP 28 - A 2HD LYS 31 12 Dist = 1.53 A 2HD1 LEU 30 - A 1HG GLN 35 7 Dist = 1.54 A HG SER 51 - A HD1 TYR 58 7 Dist = 1.59 A 1HG1 VAL 22 - A 2HZ LYS 65 13 Dist = 1.59 DISTANCES AND ANGLES We have checked your intra and intermolecular distances and angles with the procedures currently in place at PDB: ==> Bond and angle checks are performed by first computing the average rms error for all bonds and angles relative to standard values for nucleotide units [L. Clowney et al., Geometric Parameters in Nucleic Acids: Nitrogenous Bases, J.Am.Chem.Soc. 1996, 118, 509-518; A. Gelbin et al., Geometric Parameters in Nucleic Acids: Sugar and Phosphate Constituents, J.Am.Chem.Soc. 1996, 118, 519-529] and amino acid units [R.A. Engh and R. Huber, Accurate Bond and Angle Parameters for X-ray protein structure refinement, Acta Crystallogr. 1991, A47, 392-400]. Any bond or angle which deviates from the dictionary values by more than six times this computed rms error is identified as an outlier. *** Covalent Bond Lengths: The RMS deviation for covalent bonds relative to the standard dictionary is 0.009 Angstroms All covalent bonds lie within a 6.0*RMSD range about the standard dictionary values. *** Covalent Angle Values: The RMS deviation for covalent angles relative to the standard dictionary is 0.6 degrees. The following table contains a list of the covalent bond angles greater than 6.0*RMSD. Deviation Residue Chain Sequence Model AT1 - AT2 - AT3 Bond Dictionary Name ID Number Angle Value -------------------------------------------------------------------------------- 4.8 SER A 9 3 N - CA - C 116.0 111.2 4.0 THR A 56 7 N - CA - C 115.2 111.2 TORSION ANGLES The torsion angle distributions have been checked. The postscript file of the conformation rings showing the torsion angle distributions will be sent in a separate E-mail message. CHIRALITY The chirality has been checked. O1P, O2P, and hydrogen atoms which do not follow the convention defined in the IUBMB (Liebecq, C. Compendium of Biochemical Nomenclature and Related Documents, 2nd ed.; Portland Press: London and Chapel Hill, 1992) and IUPAC nomenclature (J.L. Markley, A. Bax, Y. Arata, C.W. Hilbers, R. Kaptein, B.D. Sykes, P.E. Wright and K. Wüthrich, Recommendations for the Presentation of NMR Structures of Proteins and Nucleic Acids, Pure & Appl. Chem., Vol. 70, pp. 117-142, 1998) have been standardized. Any other stereochemical violations are listed below. E/Z NOMENCLATURE E/Z nomenclature of hydrogens and/or nitrogens on Arg, Asn or Gln residues needs to be corrected to conform with the standard for E/Z orientation presented in [J.L. Markley, et al., Recommendations for the Presentation of NMR Structures of Proteins and Nucleic Acids, Pure & Appl. Chem., 1998, 70, 117-142]. Model Chain Residue Residue Atom Name Original Name Number Atom Name ----- ----- ------- ------- -------- --------- 1 A GLN 16 1HE2 1 A GLN 16 2HE2 1 A ASN 24 1HD2 1 A ASN 24 2HD2 1 A ASN 34 1HD2 1 A ASN 34 2HD2 1 A GLN 35 1HE2 1 A GLN 35 2HE2 1 A GLN 46 1HE2 1 A GLN 46 2HE2 1 A ASN 54 1HD2 1 A ASN 54 2HD2 1 A ASN 60 1HD2 1 A ASN 60 2HD2 1 A GLN 67 1HE2 1 A GLN 67 2HE2 2 A GLN 16 1HE2 2 A GLN 16 2HE2 2 A ASN 24 1HD2 2 A ASN 24 2HD2 2 A ASN 34 1HD2 2 A ASN 34 2HD2 2 A GLN 35 1HE2 2 A GLN 35 2HE2 2 A GLN 46 1HE2 2 A GLN 46 2HE2 2 A ASN 54 1HD2 2 A ASN 54 2HD2 2 A ASN 60 1HD2 2 A ASN 60 2HD2 2 A GLN 67 1HE2 2 A GLN 67 2HE2 3 A GLN 16 1HE2 3 A GLN 16 2HE2 3 A ASN 24 1HD2 3 A ASN 24 2HD2 3 A ASN 34 1HD2 3 A ASN 34 2HD2 3 A GLN 35 1HE2 3 A GLN 35 2HE2 3 A GLN 46 1HE2 3 A GLN 46 2HE2 3 A ASN 54 1HD2 3 A ASN 54 2HD2 3 A ASN 60 1HD2 3 A ASN 60 2HD2 3 A GLN 67 1HE2 3 A GLN 67 2HE2 4 A GLN 16 1HE2 4 A GLN 16 2HE2 4 A ASN 24 1HD2 4 A ASN 24 2HD2 4 A ASN 34 1HD2 4 A ASN 34 2HD2 4 A GLN 35 1HE2 4 A GLN 35 2HE2 4 A GLN 46 1HE2 4 A GLN 46 2HE2 4 A ASN 54 1HD2 4 A ASN 54 2HD2 4 A ASN 60 1HD2 4 A ASN 60 2HD2 4 A GLN 67 1HE2 4 A GLN 67 2HE2 5 A GLN 16 1HE2 5 A GLN 16 2HE2 5 A ASN 24 1HD2 5 A ASN 24 2HD2 5 A ASN 34 1HD2 5 A ASN 34 2HD2 5 A GLN 35 1HE2 5 A GLN 35 2HE2 5 A GLN 46 1HE2 5 A GLN 46 2HE2 5 A ASN 54 1HD2 5 A ASN 54 2HD2 5 A ASN 60 1HD2 5 A ASN 60 2HD2 5 A GLN 67 1HE2 5 A GLN 67 2HE2 6 A GLN 16 1HE2 6 A GLN 16 2HE2 6 A ASN 24 1HD2 6 A ASN 24 2HD2 6 A ASN 34 1HD2 6 A ASN 34 2HD2 6 A GLN 35 1HE2 6 A GLN 35 2HE2 6 A GLN 46 1HE2 6 A GLN 46 2HE2 6 A ASN 54 1HD2 6 A ASN 54 2HD2 6 A ASN 60 1HD2 6 A ASN 60 2HD2 6 A GLN 67 1HE2 6 A GLN 67 2HE2 7 A GLN 16 1HE2 7 A GLN 16 2HE2 7 A ASN 24 1HD2 7 A ASN 24 2HD2 7 A ASN 34 1HD2 7 A ASN 34 2HD2 7 A GLN 35 1HE2 7 A GLN 35 2HE2 7 A GLN 46 1HE2 7 A GLN 46 2HE2 7 A ASN 54 1HD2 7 A ASN 54 2HD2 7 A ASN 60 1HD2 7 A ASN 60 2HD2 7 A GLN 67 1HE2 7 A GLN 67 2HE2 8 A GLN 16 1HE2 8 A GLN 16 2HE2 8 A ASN 24 1HD2 8 A ASN 24 2HD2 8 A ASN 34 1HD2 8 A ASN 34 2HD2 8 A GLN 35 1HE2 8 A GLN 35 2HE2 8 A GLN 46 1HE2 8 A GLN 46 2HE2 8 A ASN 54 1HD2 8 A ASN 54 2HD2 8 A ASN 60 1HD2 8 A ASN 60 2HD2 8 A GLN 67 1HE2 8 A GLN 67 2HE2 9 A GLN 16 1HE2 9 A GLN 16 2HE2 9 A ASN 24 1HD2 9 A ASN 24 2HD2 9 A ASN 34 1HD2 9 A ASN 34 2HD2 9 A GLN 35 1HE2 9 A GLN 35 2HE2 9 A GLN 46 1HE2 9 A GLN 46 2HE2 9 A ASN 54 1HD2 9 A ASN 54 2HD2 9 A ASN 60 1HD2 9 A ASN 60 2HD2 9 A GLN 67 1HE2 9 A GLN 67 2HE2 10 A GLN 16 1HE2 10 A GLN 16 2HE2 10 A ASN 24 1HD2 10 A ASN 24 2HD2 10 A ASN 34 1HD2 10 A ASN 34 2HD2 10 A GLN 35 1HE2 10 A GLN 35 2HE2 10 A GLN 46 1HE2 10 A GLN 46 2HE2 10 A ASN 54 1HD2 10 A ASN 54 2HD2 10 A ASN 60 1HD2 10 A ASN 60 2HD2 10 A GLN 67 1HE2 10 A GLN 67 2HE2 11 A GLN 16 1HE2 11 A GLN 16 2HE2 11 A ASN 24 1HD2 11 A ASN 24 2HD2 11 A ASN 34 1HD2 11 A ASN 34 2HD2 11 A GLN 35 1HE2 11 A GLN 35 2HE2 11 A GLN 46 1HE2 11 A GLN 46 2HE2 11 A ASN 54 1HD2 11 A ASN 54 2HD2 11 A ASN 60 1HD2 11 A ASN 60 2HD2 11 A GLN 67 1HE2 11 A GLN 67 2HE2 12 A GLN 16 1HE2 12 A GLN 16 2HE2 12 A ASN 24 1HD2 12 A ASN 24 2HD2 12 A ASN 34 1HD2 12 A ASN 34 2HD2 12 A GLN 35 1HE2 12 A GLN 35 2HE2 12 A GLN 46 1HE2 12 A GLN 46 2HE2 12 A ASN 54 1HD2 12 A ASN 54 2HD2 12 A ASN 60 1HD2 12 A ASN 60 2HD2 12 A GLN 67 1HE2 12 A GLN 67 2HE2 13 A GLN 16 1HE2 13 A GLN 16 2HE2 13 A ASN 24 1HD2 13 A ASN 24 2HD2 13 A ASN 34 1HD2 13 A ASN 34 2HD2 13 A GLN 35 1HE2 13 A GLN 35 2HE2 13 A GLN 46 1HE2 13 A GLN 46 2HE2 13 A ASN 54 1HD2 13 A ASN 54 2HD2 13 A ASN 60 1HD2 13 A ASN 60 2HD2 13 A GLN 67 1HE2 13 A GLN 67 2HE2 14 A GLN 16 1HE2 14 A GLN 16 2HE2 14 A ASN 24 1HD2 14 A ASN 24 2HD2 14 A ASN 34 1HD2 14 A ASN 34 2HD2 14 A GLN 35 1HE2 14 A GLN 35 2HE2 14 A GLN 46 1HE2 14 A GLN 46 2HE2 14 A ASN 54 1HD2 14 A ASN 54 2HD2 14 A ASN 60 1HD2 14 A ASN 60 2HD2 14 A GLN 67 1HE2 14 A GLN 67 2HE2 15 A GLN 16 1HE2 15 A GLN 16 2HE2 15 A ASN 24 1HD2 15 A ASN 24 2HD2 15 A ASN 34 1HD2 15 A ASN 34 2HD2 15 A GLN 35 1HE2 15 A GLN 35 2HE2 15 A GLN 46 1HE2 15 A GLN 46 2HE2 15 A ASN 54 1HD2 15 A ASN 54 2HD2 15 A ASN 60 1HD2 15 A ASN 60 2HD2 15 A GLN 67 1HE2 15 A GLN 67 2HE2 16 A GLN 16 1HE2 16 A GLN 16 2HE2 16 A ASN 24 1HD2 16 A ASN 24 2HD2 16 A ASN 34 1HD2 16 A ASN 34 2HD2 16 A GLN 35 1HE2 16 A GLN 35 2HE2 16 A GLN 46 1HE2 16 A GLN 46 2HE2 16 A ASN 54 1HD2 16 A ASN 54 2HD2 16 A ASN 60 1HD2 16 A ASN 60 2HD2 16 A GLN 67 1HE2 16 A GLN 67 2HE2 17 A GLN 16 1HE2 17 A GLN 16 2HE2 17 A ASN 24 1HD2 17 A ASN 24 2HD2 17 A ASN 34 1HD2 17 A ASN 34 2HD2 17 A GLN 35 1HE2 17 A GLN 35 2HE2 17 A GLN 46 1HE2 17 A GLN 46 2HE2 17 A ASN 54 1HD2 17 A ASN 54 2HD2 17 A ASN 60 1HD2 17 A ASN 60 2HD2 17 A GLN 67 1HE2 17 A GLN 67 2HE2 18 A GLN 16 1HE2 18 A GLN 16 2HE2 18 A ASN 24 1HD2 18 A ASN 24 2HD2 18 A ASN 34 1HD2 18 A ASN 34 2HD2 18 A GLN 35 1HE2 18 A GLN 35 2HE2 18 A GLN 46 1HE2 18 A GLN 46 2HE2 18 A ASN 54 1HD2 18 A ASN 54 2HD2 18 A ASN 60 1HD2 18 A ASN 60 2HD2 18 A GLN 67 1HE2 18 A GLN 67 2HE2 19 A GLN 16 1HE2 19 A GLN 16 2HE2 19 A ASN 24 1HD2 19 A ASN 24 2HD2 19 A ASN 34 1HD2 19 A ASN 34 2HD2 19 A GLN 35 1HE2 19 A GLN 35 2HE2 19 A GLN 46 1HE2 19 A GLN 46 2HE2 19 A ASN 54 1HD2 19 A ASN 54 2HD2 19 A ASN 60 1HD2 19 A ASN 60 2HD2 19 A GLN 67 1HE2 19 A GLN 67 2HE2 20 A GLN 16 1HE2 20 A GLN 16 2HE2 20 A ASN 24 1HD2 20 A ASN 24 2HD2 20 A ASN 34 1HD2 20 A ASN 34 2HD2 20 A GLN 35 1HE2 20 A GLN 35 2HE2 20 A GLN 46 1HE2 20 A GLN 46 2HE2 20 A ASN 54 1HD2 20 A ASN 54 2HD2 20 A ASN 60 1HD2 20 A ASN 60 2HD2 20 A GLN 67 1HE2 20 A GLN 67 2HE2 OTHER IMPORTANT ISSUES ==> The following residues are missing: (Note: The SEQ number starts from 1 for each chain according to SEQRES sequence record.) RES MOD#C SEQ MET( 1 A -82 ) GLY( 1 A -81 ) HIS( 1 A -80 ) HIS( 1 A -79 ) HIS( 1 A -78 ) HIS( 1 A -77 ) HIS( 1 A -76 ) HIS( 1 A -75 ) SER( 1 A -74 ) HIS( 1 A -73 ) MET( 1 A -72 ) LEU( 1 A -71 ) PRO( 1 A -70 ) PRO( 1 A -69 ) GLU( 1 A -68 ) GLN( 1 A -67 ) TRP( 1 A -66 ) SER( 1 A -65 ) HIS( 1 A -64 ) THR( 1 A -63 ) THR( 1 A -62 ) VAL( 1 A -61 ) ARG( 1 A -60 ) ASN( 1 A -59 ) ALA( 1 A -58 ) LEU( 1 A -57 ) LYS( 1 A -56 ) ASP( 1 A -55 ) LEU( 1 A -54 ) LEU( 1 A -53 ) LYS( 1 A -52 ) ASP( 1 A -51 ) MET( 1 A -50 ) ASN( 1 A -49 ) GLN( 1 A -48 ) SER( 1 A -47 ) SER( 1 A -46 ) LEU( 1 A -45 ) ALA( 1 A -44 ) LYS( 1 A -43 ) GLU( 1 A -42 ) CYS( 1 A -41 ) PRO( 1 A -40 ) LEU( 1 A -39 ) SER( 1 A -38 ) GLN( 1 A -37 ) SER( 1 A -36 ) MET( 1 A -35 ) ILE( 1 A -34 ) SER( 1 A -33 ) SER( 1 A -32 ) ILE( 1 A -31 ) VAL( 1 A -30 ) ASN( 1 A -29 ) SER( 1 A -28 ) THR( 1 A -27 ) TYR( 1 A -26 ) TYR( 1 A -25 ) ALA( 1 A -24 ) ASN( 1 A -23 ) VAL( 1 A -22 ) SER( 1 A -21 ) ALA( 1 A -20 ) ALA( 1 A -19 ) LYS( 1 A -18 ) CYS( 1 A -17 ) GLN( 1 A -16 ) GLU( 1 A -15 ) PHE( 1 A -14 ) GLY( 1 A -13 ) ARG( 1 A -12 ) TRP( 1 A -11 ) TYR( 1 A -10 ) LYS( 1 A -9 ) HIS( 1 A -8 ) PHE( 1 A -7 ) LYS( 1 A -6 ) LYS( 1 A -5 ) THR( 1 A -4 ) LYS( 1 A -3 ) ASP( 1 A -2 ) MET( 1 A -1 ) MET( 1 A 0 ) MET( 2 A -82 ) GLY( 2 A -81 ) HIS( 2 A -80 ) HIS( 2 A -79 ) HIS( 2 A -78 ) HIS( 2 A -77 ) HIS( 2 A -76 ) HIS( 2 A -75 ) SER( 2 A -74 ) HIS( 2 A -73 ) MET( 2 A -72 ) LEU( 2 A -71 ) PRO( 2 A -70 ) PRO( 2 A -69 ) GLU( 2 A -68 ) GLN( 2 A -67 ) TRP( 2 A -66 ) SER( 2 A -65 ) HIS( 2 A -64 ) THR( 2 A -63 ) THR( 2 A -62 ) VAL( 2 A -61 ) ARG( 2 A -60 ) ASN( 2 A -59 ) ALA( 2 A -58 ) LEU( 2 A -57 ) LYS( 2 A -56 ) ASP( 2 A -55 ) LEU( 2 A -54 ) LEU( 2 A -53 ) LYS( 2 A -52 ) ASP( 2 A -51 ) MET( 2 A -50 ) ASN( 2 A -49 ) GLN( 2 A -48 ) SER( 2 A -47 ) SER( 2 A -46 ) LEU( 2 A -45 ) ALA( 2 A -44 ) LYS( 2 A -43 ) GLU( 2 A -42 ) CYS( 2 A -41 ) PRO( 2 A -40 ) LEU( 2 A -39 ) SER( 2 A -38 ) GLN( 2 A -37 ) SER( 2 A -36 ) MET( 2 A -35 ) ILE( 2 A -34 ) SER( 2 A -33 ) SER( 2 A -32 ) ILE( 2 A -31 ) VAL( 2 A -30 ) ASN( 2 A -29 ) SER( 2 A -28 ) THR( 2 A -27 ) TYR( 2 A -26 ) TYR( 2 A -25 ) ALA( 2 A -24 ) ASN( 2 A -23 ) VAL( 2 A -22 ) SER( 2 A -21 ) ALA( 2 A -20 ) ALA( 2 A -19 ) LYS( 2 A -18 ) CYS( 2 A -17 ) GLN( 2 A -16 ) GLU( 2 A -15 ) PHE( 2 A -14 ) GLY( 2 A -13 ) ARG( 2 A -12 ) TRP( 2 A -11 ) TYR( 2 A -10 ) LYS( 2 A -9 ) HIS( 2 A -8 ) PHE( 2 A -7 ) LYS( 2 A -6 ) LYS( 2 A -5 ) THR( 2 A -4 ) LYS( 2 A -3 ) ASP( 2 A -2 ) MET( 2 A -1 ) MET( 2 A 0 ) MET( 3 A -82 ) GLY( 3 A -81 ) HIS( 3 A -80 ) HIS( 3 A -79 ) HIS( 3 A -78 ) HIS( 3 A -77 ) HIS( 3 A -76 ) HIS( 3 A -75 ) SER( 3 A -74 ) HIS( 3 A -73 ) MET( 3 A -72 ) LEU( 3 A -71 ) PRO( 3 A -70 ) PRO( 3 A -69 ) GLU( 3 A -68 ) GLN( 3 A -67 ) TRP( 3 A -66 ) SER( 3 A -65 ) HIS( 3 A -64 ) THR( 3 A -63 ) THR( 3 A -62 ) VAL( 3 A -61 ) ARG( 3 A -60 ) ASN( 3 A -59 ) ALA( 3 A -58 ) LEU( 3 A -57 ) LYS( 3 A -56 ) ASP( 3 A -55 ) LEU( 3 A -54 ) LEU( 3 A -53 ) LYS( 3 A -52 ) ASP( 3 A -51 ) MET( 3 A -50 ) ASN( 3 A -49 ) GLN( 3 A -48 ) SER( 3 A -47 ) SER( 3 A -46 ) LEU( 3 A -45 ) ALA( 3 A -44 ) LYS( 3 A -43 ) GLU( 3 A -42 ) CYS( 3 A -41 ) PRO( 3 A -40 ) LEU( 3 A -39 ) SER( 3 A -38 ) GLN( 3 A -37 ) SER( 3 A -36 ) MET( 3 A -35 ) ILE( 3 A -34 ) SER( 3 A -33 ) SER( 3 A -32 ) ILE( 3 A -31 ) VAL( 3 A -30 ) ASN( 3 A -29 ) SER( 3 A -28 ) THR( 3 A -27 ) TYR( 3 A -26 ) TYR( 3 A -25 ) ALA( 3 A -24 ) ASN( 3 A -23 ) VAL( 3 A -22 ) SER( 3 A -21 ) ALA( 3 A -20 ) ALA( 3 A -19 ) LYS( 3 A -18 ) CYS( 3 A -17 ) GLN( 3 A -16 ) GLU( 3 A -15 ) PHE( 3 A -14 ) GLY( 3 A -13 ) ARG( 3 A -12 ) TRP( 3 A -11 ) TYR( 3 A -10 ) LYS( 3 A -9 ) HIS( 3 A -8 ) PHE( 3 A -7 ) LYS( 3 A -6 ) LYS( 3 A -5 ) THR( 3 A -4 ) LYS( 3 A -3 ) ASP( 3 A -2 ) MET( 3 A -1 ) MET( 3 A 0 ) MET( 4 A -82 ) GLY( 4 A -81 ) HIS( 4 A -80 ) HIS( 4 A -79 ) HIS( 4 A -78 ) HIS( 4 A -77 ) HIS( 4 A -76 ) HIS( 4 A -75 ) SER( 4 A -74 ) HIS( 4 A -73 ) MET( 4 A -72 ) LEU( 4 A -71 ) PRO( 4 A -70 ) PRO( 4 A -69 ) GLU( 4 A -68 ) GLN( 4 A -67 ) TRP( 4 A -66 ) SER( 4 A -65 ) HIS( 4 A -64 ) THR( 4 A -63 ) THR( 4 A -62 ) VAL( 4 A -61 ) ARG( 4 A -60 ) ASN( 4 A -59 ) ALA( 4 A -58 ) LEU( 4 A -57 ) LYS( 4 A -56 ) ASP( 4 A -55 ) LEU( 4 A -54 ) LEU( 4 A -53 ) LYS( 4 A -52 ) ASP( 4 A -51 ) MET( 4 A -50 ) ASN( 4 A -49 ) GLN( 4 A -48 ) SER( 4 A -47 ) SER( 4 A -46 ) LEU( 4 A -45 ) ALA( 4 A -44 ) LYS( 4 A -43 ) GLU( 4 A -42 ) CYS( 4 A -41 ) PRO( 4 A -40 ) LEU( 4 A -39 ) SER( 4 A -38 ) GLN( 4 A -37 ) SER( 4 A -36 ) MET( 4 A -35 ) ILE( 4 A -34 ) SER( 4 A -33 ) SER( 4 A -32 ) ILE( 4 A -31 ) VAL( 4 A -30 ) ASN( 4 A -29 ) SER( 4 A -28 ) THR( 4 A -27 ) TYR( 4 A -26 ) TYR( 4 A -25 ) ALA( 4 A -24 ) ASN( 4 A -23 ) VAL( 4 A -22 ) SER( 4 A -21 ) ALA( 4 A -20 ) ALA( 4 A -19 ) LYS( 4 A -18 ) CYS( 4 A -17 ) GLN( 4 A -16 ) GLU( 4 A -15 ) PHE( 4 A -14 ) GLY( 4 A -13 ) ARG( 4 A -12 ) TRP( 4 A -11 ) TYR( 4 A -10 ) LYS( 4 A -9 ) HIS( 4 A -8 ) PHE( 4 A -7 ) LYS( 4 A -6 ) LYS( 4 A -5 ) THR( 4 A -4 ) LYS( 4 A -3 ) ASP( 4 A -2 ) MET( 4 A -1 ) MET( 4 A 0 ) MET( 5 A -82 ) GLY( 5 A -81 ) HIS( 5 A -80 ) HIS( 5 A -79 ) HIS( 5 A -78 ) HIS( 5 A -77 ) HIS( 5 A -76 ) HIS( 5 A -75 ) SER( 5 A -74 ) HIS( 5 A -73 ) MET( 5 A -72 ) LEU( 5 A -71 ) PRO( 5 A -70 ) PRO( 5 A -69 ) GLU( 5 A -68 ) GLN( 5 A -67 ) TRP( 5 A -66 ) SER( 5 A -65 ) HIS( 5 A -64 ) THR( 5 A -63 ) THR( 5 A -62 ) VAL( 5 A -61 ) ARG( 5 A -60 ) ASN( 5 A -59 ) ALA( 5 A -58 ) LEU( 5 A -57 ) LYS( 5 A -56 ) ASP( 5 A -55 ) LEU( 5 A -54 ) LEU( 5 A -53 ) LYS( 5 A -52 ) ASP( 5 A -51 ) MET( 5 A -50 ) ASN( 5 A -49 ) GLN( 5 A -48 ) SER( 5 A -47 ) SER( 5 A -46 ) LEU( 5 A -45 ) ALA( 5 A -44 ) LYS( 5 A -43 ) GLU( 5 A -42 ) CYS( 5 A -41 ) PRO( 5 A -40 ) LEU( 5 A -39 ) SER( 5 A -38 ) GLN( 5 A -37 ) SER( 5 A -36 ) MET( 5 A -35 ) ILE( 5 A -34 ) SER( 5 A -33 ) SER( 5 A -32 ) ILE( 5 A -31 ) VAL( 5 A -30 ) ASN( 5 A -29 ) SER( 5 A -28 ) THR( 5 A -27 ) TYR( 5 A -26 ) TYR( 5 A -25 ) ALA( 5 A -24 ) ASN( 5 A -23 ) VAL( 5 A -22 ) SER( 5 A -21 ) ALA( 5 A -20 ) ALA( 5 A -19 ) LYS( 5 A -18 ) CYS( 5 A -17 ) GLN( 5 A -16 ) GLU( 5 A -15 ) PHE( 5 A -14 ) GLY( 5 A -13 ) ARG( 5 A -12 ) TRP( 5 A -11 ) TYR( 5 A -10 ) LYS( 5 A -9 ) HIS( 5 A -8 ) PHE( 5 A -7 ) LYS( 5 A -6 ) LYS( 5 A -5 ) THR( 5 A -4 ) LYS( 5 A -3 ) ASP( 5 A -2 ) MET( 5 A -1 ) MET( 5 A 0 ) MET( 6 A -82 ) GLY( 6 A -81 ) HIS( 6 A -80 ) HIS( 6 A -79 ) HIS( 6 A -78 ) HIS( 6 A -77 ) HIS( 6 A -76 ) HIS( 6 A -75 ) SER( 6 A -74 ) HIS( 6 A -73 ) MET( 6 A -72 ) LEU( 6 A -71 ) PRO( 6 A -70 ) PRO( 6 A -69 ) GLU( 6 A -68 ) GLN( 6 A -67 ) TRP( 6 A -66 ) SER( 6 A -65 ) HIS( 6 A -64 ) THR( 6 A -63 ) THR( 6 A -62 ) VAL( 6 A -61 ) ARG( 6 A -60 ) ASN( 6 A -59 ) ALA( 6 A -58 ) LEU( 6 A -57 ) LYS( 6 A -56 ) ASP( 6 A -55 ) LEU( 6 A -54 ) LEU( 6 A -53 ) LYS( 6 A -52 ) ASP( 6 A -51 ) MET( 6 A -50 ) ASN( 6 A -49 ) GLN( 6 A -48 ) SER( 6 A -47 ) SER( 6 A -46 ) LEU( 6 A -45 ) ALA( 6 A -44 ) LYS( 6 A -43 ) GLU( 6 A -42 ) CYS( 6 A -41 ) PRO( 6 A -40 ) LEU( 6 A -39 ) SER( 6 A -38 ) GLN( 6 A -37 ) SER( 6 A -36 ) MET( 6 A -35 ) ILE( 6 A -34 ) SER( 6 A -33 ) SER( 6 A -32 ) ILE( 6 A -31 ) VAL( 6 A -30 ) ASN( 6 A -29 ) SER( 6 A -28 ) THR( 6 A -27 ) TYR( 6 A -26 ) TYR( 6 A -25 ) ALA( 6 A -24 ) ASN( 6 A -23 ) VAL( 6 A -22 ) SER( 6 A -21 ) ALA( 6 A -20 ) ALA( 6 A -19 ) LYS( 6 A -18 ) CYS( 6 A -17 ) GLN( 6 A -16 ) GLU( 6 A -15 ) PHE( 6 A -14 ) GLY( 6 A -13 ) ARG( 6 A -12 ) TRP( 6 A -11 ) TYR( 6 A -10 ) LYS( 6 A -9 ) HIS( 6 A -8 ) PHE( 6 A -7 ) LYS( 6 A -6 ) LYS( 6 A -5 ) THR( 6 A -4 ) LYS( 6 A -3 ) ASP( 6 A -2 ) MET( 6 A -1 ) MET( 6 A 0 ) MET( 7 A -82 ) GLY( 7 A -81 ) HIS( 7 A -80 ) HIS( 7 A -79 ) HIS( 7 A -78 ) HIS( 7 A -77 ) HIS( 7 A -76 ) HIS( 7 A -75 ) SER( 7 A -74 ) HIS( 7 A -73 ) MET( 7 A -72 ) LEU( 7 A -71 ) PRO( 7 A -70 ) PRO( 7 A -69 ) GLU( 7 A -68 ) GLN( 7 A -67 ) TRP( 7 A -66 ) SER( 7 A -65 ) HIS( 7 A -64 ) THR( 7 A -63 ) THR( 7 A -62 ) VAL( 7 A -61 ) ARG( 7 A -60 ) ASN( 7 A -59 ) ALA( 7 A -58 ) LEU( 7 A -57 ) LYS( 7 A -56 ) ASP( 7 A -55 ) LEU( 7 A -54 ) LEU( 7 A -53 ) LYS( 7 A -52 ) ASP( 7 A -51 ) MET( 7 A -50 ) ASN( 7 A -49 ) GLN( 7 A -48 ) SER( 7 A -47 ) SER( 7 A -46 ) LEU( 7 A -45 ) ALA( 7 A -44 ) LYS( 7 A -43 ) GLU( 7 A -42 ) CYS( 7 A -41 ) PRO( 7 A -40 ) LEU( 7 A -39 ) SER( 7 A -38 ) GLN( 7 A -37 ) SER( 7 A -36 ) MET( 7 A -35 ) ILE( 7 A -34 ) SER( 7 A -33 ) SER( 7 A -32 ) ILE( 7 A -31 ) VAL( 7 A -30 ) ASN( 7 A -29 ) SER( 7 A -28 ) THR( 7 A -27 ) TYR( 7 A -26 ) TYR( 7 A -25 ) ALA( 7 A -24 ) ASN( 7 A -23 ) VAL( 7 A -22 ) SER( 7 A -21 ) ALA( 7 A -20 ) ALA( 7 A -19 ) LYS( 7 A -18 ) CYS( 7 A -17 ) GLN( 7 A -16 ) GLU( 7 A -15 ) PHE( 7 A -14 ) GLY( 7 A -13 ) ARG( 7 A -12 ) TRP( 7 A -11 ) TYR( 7 A -10 ) LYS( 7 A -9 ) HIS( 7 A -8 ) PHE( 7 A -7 ) LYS( 7 A -6 ) LYS( 7 A -5 ) THR( 7 A -4 ) LYS( 7 A -3 ) ASP( 7 A -2 ) MET( 7 A -1 ) MET( 7 A 0 ) MET( 8 A -82 ) GLY( 8 A -81 ) HIS( 8 A -80 ) HIS( 8 A -79 ) HIS( 8 A -78 ) HIS( 8 A -77 ) HIS( 8 A -76 ) HIS( 8 A -75 ) SER( 8 A -74 ) HIS( 8 A -73 ) MET( 8 A -72 ) LEU( 8 A -71 ) PRO( 8 A -70 ) PRO( 8 A -69 ) GLU( 8 A -68 ) GLN( 8 A -67 ) TRP( 8 A -66 ) SER( 8 A -65 ) HIS( 8 A -64 ) THR( 8 A -63 ) THR( 8 A -62 ) VAL( 8 A -61 ) ARG( 8 A -60 ) ASN( 8 A -59 ) ALA( 8 A -58 ) LEU( 8 A -57 ) LYS( 8 A -56 ) ASP( 8 A -55 ) LEU( 8 A -54 ) LEU( 8 A -53 ) LYS( 8 A -52 ) ASP( 8 A -51 ) MET( 8 A -50 ) ASN( 8 A -49 ) GLN( 8 A -48 ) SER( 8 A -47 ) SER( 8 A -46 ) LEU( 8 A -45 ) ALA( 8 A -44 ) LYS( 8 A -43 ) GLU( 8 A -42 ) CYS( 8 A -41 ) PRO( 8 A -40 ) LEU( 8 A -39 ) SER( 8 A -38 ) GLN( 8 A -37 ) SER( 8 A -36 ) MET( 8 A -35 ) ILE( 8 A -34 ) SER( 8 A -33 ) SER( 8 A -32 ) ILE( 8 A -31 ) VAL( 8 A -30 ) ASN( 8 A -29 ) SER( 8 A -28 ) THR( 8 A -27 ) TYR( 8 A -26 ) TYR( 8 A -25 ) ALA( 8 A -24 ) ASN( 8 A -23 ) VAL( 8 A -22 ) SER( 8 A -21 ) ALA( 8 A -20 ) ALA( 8 A -19 ) LYS( 8 A -18 ) CYS( 8 A -17 ) GLN( 8 A -16 ) GLU( 8 A -15 ) PHE( 8 A -14 ) GLY( 8 A -13 ) ARG( 8 A -12 ) TRP( 8 A -11 ) TYR( 8 A -10 ) LYS( 8 A -9 ) HIS( 8 A -8 ) PHE( 8 A -7 ) LYS( 8 A -6 ) LYS( 8 A -5 ) THR( 8 A -4 ) LYS( 8 A -3 ) ASP( 8 A -2 ) MET( 8 A -1 ) MET( 8 A 0 ) MET( 9 A -82 ) GLY( 9 A -81 ) HIS( 9 A -80 ) HIS( 9 A -79 ) HIS( 9 A -78 ) HIS( 9 A -77 ) HIS( 9 A -76 ) HIS( 9 A -75 ) SER( 9 A -74 ) HIS( 9 A -73 ) MET( 9 A -72 ) LEU( 9 A -71 ) PRO( 9 A -70 ) PRO( 9 A -69 ) GLU( 9 A -68 ) GLN( 9 A -67 ) TRP( 9 A -66 ) SER( 9 A -65 ) HIS( 9 A -64 ) THR( 9 A -63 ) THR( 9 A -62 ) VAL( 9 A -61 ) ARG( 9 A -60 ) ASN( 9 A -59 ) ALA( 9 A -58 ) LEU( 9 A -57 ) LYS( 9 A -56 ) ASP( 9 A -55 ) LEU( 9 A -54 ) LEU( 9 A -53 ) LYS( 9 A -52 ) ASP( 9 A -51 ) MET( 9 A -50 ) ASN( 9 A -49 ) GLN( 9 A -48 ) SER( 9 A -47 ) SER( 9 A -46 ) LEU( 9 A -45 ) ALA( 9 A -44 ) LYS( 9 A -43 ) GLU( 9 A -42 ) CYS( 9 A -41 ) PRO( 9 A -40 ) LEU( 9 A -39 ) SER( 9 A -38 ) GLN( 9 A -37 ) SER( 9 A -36 ) MET( 9 A -35 ) ILE( 9 A -34 ) SER( 9 A -33 ) SER( 9 A -32 ) ILE( 9 A -31 ) VAL( 9 A -30 ) ASN( 9 A -29 ) SER( 9 A -28 ) THR( 9 A -27 ) TYR( 9 A -26 ) TYR( 9 A -25 ) ALA( 9 A -24 ) ASN( 9 A -23 ) VAL( 9 A -22 ) SER( 9 A -21 ) ALA( 9 A -20 ) ALA( 9 A -19 ) LYS( 9 A -18 ) CYS( 9 A -17 ) GLN( 9 A -16 ) GLU( 9 A -15 ) PHE( 9 A -14 ) GLY( 9 A -13 ) ARG( 9 A -12 ) TRP( 9 A -11 ) TYR( 9 A -10 ) LYS( 9 A -9 ) HIS( 9 A -8 ) PHE( 9 A -7 ) LYS( 9 A -6 ) LYS( 9 A -5 ) THR( 9 A -4 ) LYS( 9 A -3 ) ASP( 9 A -2 ) MET( 9 A -1 ) MET( 9 A 0 ) MET( 10 A -82 ) GLY( 10 A -81 ) HIS( 10 A -80 ) HIS( 10 A -79 ) HIS( 10 A -78 ) HIS( 10 A -77 ) HIS( 10 A -76 ) HIS( 10 A -75 ) SER( 10 A -74 ) HIS( 10 A -73 ) MET( 10 A -72 ) LEU( 10 A -71 ) PRO( 10 A -70 ) PRO( 10 A -69 ) GLU( 10 A -68 ) GLN( 10 A -67 ) TRP( 10 A -66 ) SER( 10 A -65 ) HIS( 10 A -64 ) THR( 10 A -63 ) THR( 10 A -62 ) VAL( 10 A -61 ) ARG( 10 A -60 ) ASN( 10 A -59 ) ALA( 10 A -58 ) LEU( 10 A -57 ) LYS( 10 A -56 ) ASP( 10 A -55 ) LEU( 10 A -54 ) LEU( 10 A -53 ) LYS( 10 A -52 ) ASP( 10 A -51 ) MET( 10 A -50 ) ASN( 10 A -49 ) GLN( 10 A -48 ) SER( 10 A -47 ) SER( 10 A -46 ) LEU( 10 A -45 ) ALA( 10 A -44 ) LYS( 10 A -43 ) GLU( 10 A -42 ) CYS( 10 A -41 ) PRO( 10 A -40 ) LEU( 10 A -39 ) SER( 10 A -38 ) GLN( 10 A -37 ) SER( 10 A -36 ) MET( 10 A -35 ) ILE( 10 A -34 ) SER( 10 A -33 ) SER( 10 A -32 ) ILE( 10 A -31 ) VAL( 10 A -30 ) ASN( 10 A -29 ) SER( 10 A -28 ) THR( 10 A -27 ) TYR( 10 A -26 ) TYR( 10 A -25 ) ALA( 10 A -24 ) ASN( 10 A -23 ) VAL( 10 A -22 ) SER( 10 A -21 ) ALA( 10 A -20 ) ALA( 10 A -19 ) LYS( 10 A -18 ) CYS( 10 A -17 ) GLN( 10 A -16 ) GLU( 10 A -15 ) PHE( 10 A -14 ) GLY( 10 A -13 ) ARG( 10 A -12 ) TRP( 10 A -11 ) TYR( 10 A -10 ) LYS( 10 A -9 ) HIS( 10 A -8 ) PHE( 10 A -7 ) LYS( 10 A -6 ) LYS( 10 A -5 ) THR( 10 A -4 ) LYS( 10 A -3 ) ASP( 10 A -2 ) MET( 10 A -1 ) MET( 10 A 0 ) MET( 11 A -82 ) GLY( 11 A -81 ) HIS( 11 A -80 ) HIS( 11 A -79 ) HIS( 11 A -78 ) HIS( 11 A -77 ) HIS( 11 A -76 ) HIS( 11 A -75 ) SER( 11 A -74 ) HIS( 11 A -73 ) MET( 11 A -72 ) LEU( 11 A -71 ) PRO( 11 A -70 ) PRO( 11 A -69 ) GLU( 11 A -68 ) GLN( 11 A -67 ) TRP( 11 A -66 ) SER( 11 A -65 ) HIS( 11 A -64 ) THR( 11 A -63 ) THR( 11 A -62 ) VAL( 11 A -61 ) ARG( 11 A -60 ) ASN( 11 A -59 ) ALA( 11 A -58 ) LEU( 11 A -57 ) LYS( 11 A -56 ) ASP( 11 A -55 ) LEU( 11 A -54 ) LEU( 11 A -53 ) LYS( 11 A -52 ) ASP( 11 A -51 ) MET( 11 A -50 ) ASN( 11 A -49 ) GLN( 11 A -48 ) SER( 11 A -47 ) SER( 11 A -46 ) LEU( 11 A -45 ) ALA( 11 A -44 ) LYS( 11 A -43 ) GLU( 11 A -42 ) CYS( 11 A -41 ) PRO( 11 A -40 ) LEU( 11 A -39 ) SER( 11 A -38 ) GLN( 11 A -37 ) SER( 11 A -36 ) MET( 11 A -35 ) ILE( 11 A -34 ) SER( 11 A -33 ) SER( 11 A -32 ) ILE( 11 A -31 ) VAL( 11 A -30 ) ASN( 11 A -29 ) SER( 11 A -28 ) THR( 11 A -27 ) TYR( 11 A -26 ) TYR( 11 A -25 ) ALA( 11 A -24 ) ASN( 11 A -23 ) VAL( 11 A -22 ) SER( 11 A -21 ) ALA( 11 A -20 ) ALA( 11 A -19 ) LYS( 11 A -18 ) CYS( 11 A -17 ) GLN( 11 A -16 ) GLU( 11 A -15 ) PHE( 11 A -14 ) GLY( 11 A -13 ) ARG( 11 A -12 ) TRP( 11 A -11 ) TYR( 11 A -10 ) LYS( 11 A -9 ) HIS( 11 A -8 ) PHE( 11 A -7 ) LYS( 11 A -6 ) LYS( 11 A -5 ) THR( 11 A -4 ) LYS( 11 A -3 ) ASP( 11 A -2 ) MET( 11 A -1 ) MET( 11 A 0 ) MET( 12 A -82 ) GLY( 12 A -81 ) HIS( 12 A -80 ) HIS( 12 A -79 ) HIS( 12 A -78 ) HIS( 12 A -77 ) HIS( 12 A -76 ) HIS( 12 A -75 ) SER( 12 A -74 ) HIS( 12 A -73 ) MET( 12 A -72 ) LEU( 12 A -71 ) PRO( 12 A -70 ) PRO( 12 A -69 ) GLU( 12 A -68 ) GLN( 12 A -67 ) TRP( 12 A -66 ) SER( 12 A -65 ) HIS( 12 A -64 ) THR( 12 A -63 ) THR( 12 A -62 ) VAL( 12 A -61 ) ARG( 12 A -60 ) ASN( 12 A -59 ) ALA( 12 A -58 ) LEU( 12 A -57 ) LYS( 12 A -56 ) ASP( 12 A -55 ) LEU( 12 A -54 ) LEU( 12 A -53 ) LYS( 12 A -52 ) ASP( 12 A -51 ) MET( 12 A -50 ) ASN( 12 A -49 ) GLN( 12 A -48 ) SER( 12 A -47 ) SER( 12 A -46 ) LEU( 12 A -45 ) ALA( 12 A -44 ) LYS( 12 A -43 ) GLU( 12 A -42 ) CYS( 12 A -41 ) PRO( 12 A -40 ) LEU( 12 A -39 ) SER( 12 A -38 ) GLN( 12 A -37 ) SER( 12 A -36 ) MET( 12 A -35 ) ILE( 12 A -34 ) SER( 12 A -33 ) SER( 12 A -32 ) ILE( 12 A -31 ) VAL( 12 A -30 ) ASN( 12 A -29 ) SER( 12 A -28 ) THR( 12 A -27 ) TYR( 12 A -26 ) TYR( 12 A -25 ) ALA( 12 A -24 ) ASN( 12 A -23 ) VAL( 12 A -22 ) SER( 12 A -21 ) ALA( 12 A -20 ) ALA( 12 A -19 ) LYS( 12 A -18 ) CYS( 12 A -17 ) GLN( 12 A -16 ) GLU( 12 A -15 ) PHE( 12 A -14 ) GLY( 12 A -13 ) ARG( 12 A -12 ) TRP( 12 A -11 ) TYR( 12 A -10 ) LYS( 12 A -9 ) HIS( 12 A -8 ) PHE( 12 A -7 ) LYS( 12 A -6 ) LYS( 12 A -5 ) THR( 12 A -4 ) LYS( 12 A -3 ) ASP( 12 A -2 ) MET( 12 A -1 ) MET( 12 A 0 ) MET( 13 A -82 ) GLY( 13 A -81 ) HIS( 13 A -80 ) HIS( 13 A -79 ) HIS( 13 A -78 ) HIS( 13 A -77 ) HIS( 13 A -76 ) HIS( 13 A -75 ) SER( 13 A -74 ) HIS( 13 A -73 ) MET( 13 A -72 ) LEU( 13 A -71 ) PRO( 13 A -70 ) PRO( 13 A -69 ) GLU( 13 A -68 ) GLN( 13 A -67 ) TRP( 13 A -66 ) SER( 13 A -65 ) HIS( 13 A -64 ) THR( 13 A -63 ) THR( 13 A -62 ) VAL( 13 A -61 ) ARG( 13 A -60 ) ASN( 13 A -59 ) ALA( 13 A -58 ) LEU( 13 A -57 ) LYS( 13 A -56 ) ASP( 13 A -55 ) LEU( 13 A -54 ) LEU( 13 A -53 ) LYS( 13 A -52 ) ASP( 13 A -51 ) MET( 13 A -50 ) ASN( 13 A -49 ) GLN( 13 A -48 ) SER( 13 A -47 ) SER( 13 A -46 ) LEU( 13 A -45 ) ALA( 13 A -44 ) LYS( 13 A -43 ) GLU( 13 A -42 ) CYS( 13 A -41 ) PRO( 13 A -40 ) LEU( 13 A -39 ) SER( 13 A -38 ) GLN( 13 A -37 ) SER( 13 A -36 ) MET( 13 A -35 ) ILE( 13 A -34 ) SER( 13 A -33 ) SER( 13 A -32 ) ILE( 13 A -31 ) VAL( 13 A -30 ) ASN( 13 A -29 ) SER( 13 A -28 ) THR( 13 A -27 ) TYR( 13 A -26 ) TYR( 13 A -25 ) ALA( 13 A -24 ) ASN( 13 A -23 ) VAL( 13 A -22 ) SER( 13 A -21 ) ALA( 13 A -20 ) ALA( 13 A -19 ) LYS( 13 A -18 ) CYS( 13 A -17 ) GLN( 13 A -16 ) GLU( 13 A -15 ) PHE( 13 A -14 ) GLY( 13 A -13 ) ARG( 13 A -12 ) TRP( 13 A -11 ) TYR( 13 A -10 ) LYS( 13 A -9 ) HIS( 13 A -8 ) PHE( 13 A -7 ) LYS( 13 A -6 ) LYS( 13 A -5 ) THR( 13 A -4 ) LYS( 13 A -3 ) ASP( 13 A -2 ) MET( 13 A -1 ) MET( 13 A 0 ) MET( 14 A -82 ) GLY( 14 A -81 ) HIS( 14 A -80 ) HIS( 14 A -79 ) HIS( 14 A -78 ) HIS( 14 A -77 ) HIS( 14 A -76 ) HIS( 14 A -75 ) SER( 14 A -74 ) HIS( 14 A -73 ) MET( 14 A -72 ) LEU( 14 A -71 ) PRO( 14 A -70 ) PRO( 14 A -69 ) GLU( 14 A -68 ) GLN( 14 A -67 ) TRP( 14 A -66 ) SER( 14 A -65 ) HIS( 14 A -64 ) THR( 14 A -63 ) THR( 14 A -62 ) VAL( 14 A -61 ) ARG( 14 A -60 ) ASN( 14 A -59 ) ALA( 14 A -58 ) LEU( 14 A -57 ) LYS( 14 A -56 ) ASP( 14 A -55 ) LEU( 14 A -54 ) LEU( 14 A -53 ) LYS( 14 A -52 ) ASP( 14 A -51 ) MET( 14 A -50 ) ASN( 14 A -49 ) GLN( 14 A -48 ) SER( 14 A -47 ) SER( 14 A -46 ) LEU( 14 A -45 ) ALA( 14 A -44 ) LYS( 14 A -43 ) GLU( 14 A -42 ) CYS( 14 A -41 ) PRO( 14 A -40 ) LEU( 14 A -39 ) SER( 14 A -38 ) GLN( 14 A -37 ) SER( 14 A -36 ) MET( 14 A -35 ) ILE( 14 A -34 ) SER( 14 A -33 ) SER( 14 A -32 ) ILE( 14 A -31 ) VAL( 14 A -30 ) ASN( 14 A -29 ) SER( 14 A -28 ) THR( 14 A -27 ) TYR( 14 A -26 ) TYR( 14 A -25 ) ALA( 14 A -24 ) ASN( 14 A -23 ) VAL( 14 A -22 ) SER( 14 A -21 ) ALA( 14 A -20 ) ALA( 14 A -19 ) LYS( 14 A -18 ) CYS( 14 A -17 ) GLN( 14 A -16 ) GLU( 14 A -15 ) PHE( 14 A -14 ) GLY( 14 A -13 ) ARG( 14 A -12 ) TRP( 14 A -11 ) TYR( 14 A -10 ) LYS( 14 A -9 ) HIS( 14 A -8 ) PHE( 14 A -7 ) LYS( 14 A -6 ) LYS( 14 A -5 ) THR( 14 A -4 ) LYS( 14 A -3 ) ASP( 14 A -2 ) MET( 14 A -1 ) MET( 14 A 0 ) MET( 15 A -82 ) GLY( 15 A -81 ) HIS( 15 A -80 ) HIS( 15 A -79 ) HIS( 15 A -78 ) HIS( 15 A -77 ) HIS( 15 A -76 ) HIS( 15 A -75 ) SER( 15 A -74 ) HIS( 15 A -73 ) MET( 15 A -72 ) LEU( 15 A -71 ) PRO( 15 A -70 ) PRO( 15 A -69 ) GLU( 15 A -68 ) GLN( 15 A -67 ) TRP( 15 A -66 ) SER( 15 A -65 ) HIS( 15 A -64 ) THR( 15 A -63 ) THR( 15 A -62 ) VAL( 15 A -61 ) ARG( 15 A -60 ) ASN( 15 A -59 ) ALA( 15 A -58 ) LEU( 15 A -57 ) LYS( 15 A -56 ) ASP( 15 A -55 ) LEU( 15 A -54 ) LEU( 15 A -53 ) LYS( 15 A -52 ) ASP( 15 A -51 ) MET( 15 A -50 ) ASN( 15 A -49 ) GLN( 15 A -48 ) SER( 15 A -47 ) SER( 15 A -46 ) LEU( 15 A -45 ) ALA( 15 A -44 ) LYS( 15 A -43 ) GLU( 15 A -42 ) CYS( 15 A -41 ) PRO( 15 A -40 ) LEU( 15 A -39 ) SER( 15 A -38 ) GLN( 15 A -37 ) SER( 15 A -36 ) MET( 15 A -35 ) ILE( 15 A -34 ) SER( 15 A -33 ) SER( 15 A -32 ) ILE( 15 A -31 ) VAL( 15 A -30 ) ASN( 15 A -29 ) SER( 15 A -28 ) THR( 15 A -27 ) TYR( 15 A -26 ) TYR( 15 A -25 ) ALA( 15 A -24 ) ASN( 15 A -23 ) VAL( 15 A -22 ) SER( 15 A -21 ) ALA( 15 A -20 ) ALA( 15 A -19 ) LYS( 15 A -18 ) CYS( 15 A -17 ) GLN( 15 A -16 ) GLU( 15 A -15 ) PHE( 15 A -14 ) GLY( 15 A -13 ) ARG( 15 A -12 ) TRP( 15 A -11 ) TYR( 15 A -10 ) LYS( 15 A -9 ) HIS( 15 A -8 ) PHE( 15 A -7 ) LYS( 15 A -6 ) LYS( 15 A -5 ) THR( 15 A -4 ) LYS( 15 A -3 ) ASP( 15 A -2 ) MET( 15 A -1 ) MET( 15 A 0 ) MET( 16 A -82 ) GLY( 16 A -81 ) HIS( 16 A -80 ) HIS( 16 A -79 ) HIS( 16 A -78 ) HIS( 16 A -77 ) HIS( 16 A -76 ) HIS( 16 A -75 ) SER( 16 A -74 ) HIS( 16 A -73 ) MET( 16 A -72 ) LEU( 16 A -71 ) PRO( 16 A -70 ) PRO( 16 A -69 ) GLU( 16 A -68 ) GLN( 16 A -67 ) TRP( 16 A -66 ) SER( 16 A -65 ) HIS( 16 A -64 ) THR( 16 A -63 ) THR( 16 A -62 ) VAL( 16 A -61 ) ARG( 16 A -60 ) ASN( 16 A -59 ) ALA( 16 A -58 ) LEU( 16 A -57 ) LYS( 16 A -56 ) ASP( 16 A -55 ) LEU( 16 A -54 ) LEU( 16 A -53 ) LYS( 16 A -52 ) ASP( 16 A -51 ) MET( 16 A -50 ) ASN( 16 A -49 ) GLN( 16 A -48 ) SER( 16 A -47 ) SER( 16 A -46 ) LEU( 16 A -45 ) ALA( 16 A -44 ) LYS( 16 A -43 ) GLU( 16 A -42 ) CYS( 16 A -41 ) PRO( 16 A -40 ) LEU( 16 A -39 ) SER( 16 A -38 ) GLN( 16 A -37 ) SER( 16 A -36 ) MET( 16 A -35 ) ILE( 16 A -34 ) SER( 16 A -33 ) SER( 16 A -32 ) ILE( 16 A -31 ) VAL( 16 A -30 ) ASN( 16 A -29 ) SER( 16 A -28 ) THR( 16 A -27 ) TYR( 16 A -26 ) TYR( 16 A -25 ) ALA( 16 A -24 ) ASN( 16 A -23 ) VAL( 16 A -22 ) SER( 16 A -21 ) ALA( 16 A -20 ) ALA( 16 A -19 ) LYS( 16 A -18 ) CYS( 16 A -17 ) GLN( 16 A -16 ) GLU( 16 A -15 ) PHE( 16 A -14 ) GLY( 16 A -13 ) ARG( 16 A -12 ) TRP( 16 A -11 ) TYR( 16 A -10 ) LYS( 16 A -9 ) HIS( 16 A -8 ) PHE( 16 A -7 ) LYS( 16 A -6 ) LYS( 16 A -5 ) THR( 16 A -4 ) LYS( 16 A -3 ) ASP( 16 A -2 ) MET( 16 A -1 ) MET( 16 A 0 ) MET( 17 A -82 ) GLY( 17 A -81 ) HIS( 17 A -80 ) HIS( 17 A -79 ) HIS( 17 A -78 ) HIS( 17 A -77 ) HIS( 17 A -76 ) HIS( 17 A -75 ) SER( 17 A -74 ) HIS( 17 A -73 ) MET( 17 A -72 ) LEU( 17 A -71 ) PRO( 17 A -70 ) PRO( 17 A -69 ) GLU( 17 A -68 ) GLN( 17 A -67 ) TRP( 17 A -66 ) SER( 17 A -65 ) HIS( 17 A -64 ) THR( 17 A -63 ) THR( 17 A -62 ) VAL( 17 A -61 ) ARG( 17 A -60 ) ASN( 17 A -59 ) ALA( 17 A -58 ) LEU( 17 A -57 ) LYS( 17 A -56 ) ASP( 17 A -55 ) LEU( 17 A -54 ) LEU( 17 A -53 ) LYS( 17 A -52 ) ASP( 17 A -51 ) MET( 17 A -50 ) ASN( 17 A -49 ) GLN( 17 A -48 ) SER( 17 A -47 ) SER( 17 A -46 ) LEU( 17 A -45 ) ALA( 17 A -44 ) LYS( 17 A -43 ) GLU( 17 A -42 ) CYS( 17 A -41 ) PRO( 17 A -40 ) LEU( 17 A -39 ) SER( 17 A -38 ) GLN( 17 A -37 ) SER( 17 A -36 ) MET( 17 A -35 ) ILE( 17 A -34 ) SER( 17 A -33 ) SER( 17 A -32 ) ILE( 17 A -31 ) VAL( 17 A -30 ) ASN( 17 A -29 ) SER( 17 A -28 ) THR( 17 A -27 ) TYR( 17 A -26 ) TYR( 17 A -25 ) ALA( 17 A -24 ) ASN( 17 A -23 ) VAL( 17 A -22 ) SER( 17 A -21 ) ALA( 17 A -20 ) ALA( 17 A -19 ) LYS( 17 A -18 ) CYS( 17 A -17 ) GLN( 17 A -16 ) GLU( 17 A -15 ) PHE( 17 A -14 ) GLY( 17 A -13 ) ARG( 17 A -12 ) TRP( 17 A -11 ) TYR( 17 A -10 ) LYS( 17 A -9 ) HIS( 17 A -8 ) PHE( 17 A -7 ) LYS( 17 A -6 ) LYS( 17 A -5 ) THR( 17 A -4 ) LYS( 17 A -3 ) ASP( 17 A -2 ) MET( 17 A -1 ) MET( 17 A 0 ) MET( 18 A -82 ) GLY( 18 A -81 ) HIS( 18 A -80 ) HIS( 18 A -79 ) HIS( 18 A -78 ) HIS( 18 A -77 ) HIS( 18 A -76 ) HIS( 18 A -75 ) SER( 18 A -74 ) HIS( 18 A -73 ) MET( 18 A -72 ) LEU( 18 A -71 ) PRO( 18 A -70 ) PRO( 18 A -69 ) GLU( 18 A -68 ) GLN( 18 A -67 ) TRP( 18 A -66 ) SER( 18 A -65 ) HIS( 18 A -64 ) THR( 18 A -63 ) THR( 18 A -62 ) VAL( 18 A -61 ) ARG( 18 A -60 ) ASN( 18 A -59 ) ALA( 18 A -58 ) LEU( 18 A -57 ) LYS( 18 A -56 ) ASP( 18 A -55 ) LEU( 18 A -54 ) LEU( 18 A -53 ) LYS( 18 A -52 ) ASP( 18 A -51 ) MET( 18 A -50 ) ASN( 18 A -49 ) GLN( 18 A -48 ) SER( 18 A -47 ) SER( 18 A -46 ) LEU( 18 A -45 ) ALA( 18 A -44 ) LYS( 18 A -43 ) GLU( 18 A -42 ) CYS( 18 A -41 ) PRO( 18 A -40 ) LEU( 18 A -39 ) SER( 18 A -38 ) GLN( 18 A -37 ) SER( 18 A -36 ) MET( 18 A -35 ) ILE( 18 A -34 ) SER( 18 A -33 ) SER( 18 A -32 ) ILE( 18 A -31 ) VAL( 18 A -30 ) ASN( 18 A -29 ) SER( 18 A -28 ) THR( 18 A -27 ) TYR( 18 A -26 ) TYR( 18 A -25 ) ALA( 18 A -24 ) ASN( 18 A -23 ) VAL( 18 A -22 ) SER( 18 A -21 ) ALA( 18 A -20 ) ALA( 18 A -19 ) LYS( 18 A -18 ) CYS( 18 A -17 ) GLN( 18 A -16 ) GLU( 18 A -15 ) PHE( 18 A -14 ) GLY( 18 A -13 ) ARG( 18 A -12 ) TRP( 18 A -11 ) TYR( 18 A -10 ) LYS( 18 A -9 ) HIS( 18 A -8 ) PHE( 18 A -7 ) LYS( 18 A -6 ) LYS( 18 A -5 ) THR( 18 A -4 ) LYS( 18 A -3 ) ASP( 18 A -2 ) MET( 18 A -1 ) MET( 18 A 0 ) MET( 19 A -82 ) GLY( 19 A -81 ) HIS( 19 A -80 ) HIS( 19 A -79 ) HIS( 19 A -78 ) HIS( 19 A -77 ) HIS( 19 A -76 ) HIS( 19 A -75 ) SER( 19 A -74 ) HIS( 19 A -73 ) MET( 19 A -72 ) LEU( 19 A -71 ) PRO( 19 A -70 ) PRO( 19 A -69 ) GLU( 19 A -68 ) GLN( 19 A -67 ) TRP( 19 A -66 ) SER( 19 A -65 ) HIS( 19 A -64 ) THR( 19 A -63 ) THR( 19 A -62 ) VAL( 19 A -61 ) ARG( 19 A -60 ) ASN( 19 A -59 ) ALA( 19 A -58 ) LEU( 19 A -57 ) LYS( 19 A -56 ) ASP( 19 A -55 ) LEU( 19 A -54 ) LEU( 19 A -53 ) LYS( 19 A -52 ) ASP( 19 A -51 ) MET( 19 A -50 ) ASN( 19 A -49 ) GLN( 19 A -48 ) SER( 19 A -47 ) SER( 19 A -46 ) LEU( 19 A -45 ) ALA( 19 A -44 ) LYS( 19 A -43 ) GLU( 19 A -42 ) CYS( 19 A -41 ) PRO( 19 A -40 ) LEU( 19 A -39 ) SER( 19 A -38 ) GLN( 19 A -37 ) SER( 19 A -36 ) MET( 19 A -35 ) ILE( 19 A -34 ) SER( 19 A -33 ) SER( 19 A -32 ) ILE( 19 A -31 ) VAL( 19 A -30 ) ASN( 19 A -29 ) SER( 19 A -28 ) THR( 19 A -27 ) TYR( 19 A -26 ) TYR( 19 A -25 ) ALA( 19 A -24 ) ASN( 19 A -23 ) VAL( 19 A -22 ) SER( 19 A -21 ) ALA( 19 A -20 ) ALA( 19 A -19 ) LYS( 19 A -18 ) CYS( 19 A -17 ) GLN( 19 A -16 ) GLU( 19 A -15 ) PHE( 19 A -14 ) GLY( 19 A -13 ) ARG( 19 A -12 ) TRP( 19 A -11 ) TYR( 19 A -10 ) LYS( 19 A -9 ) HIS( 19 A -8 ) PHE( 19 A -7 ) LYS( 19 A -6 ) LYS( 19 A -5 ) THR( 19 A -4 ) LYS( 19 A -3 ) ASP( 19 A -2 ) MET( 19 A -1 ) MET( 19 A 0 ) MET( 20 A -82 ) GLY( 20 A -81 ) HIS( 20 A -80 ) HIS( 20 A -79 ) HIS( 20 A -78 ) HIS( 20 A -77 ) HIS( 20 A -76 ) HIS( 20 A -75 ) SER( 20 A -74 ) HIS( 20 A -73 ) MET( 20 A -72 ) LEU( 20 A -71 ) PRO( 20 A -70 ) PRO( 20 A -69 ) GLU( 20 A -68 ) GLN( 20 A -67 ) TRP( 20 A -66 ) SER( 20 A -65 ) HIS( 20 A -64 ) THR( 20 A -63 ) THR( 20 A -62 ) VAL( 20 A -61 ) ARG( 20 A -60 ) ASN( 20 A -59 ) ALA( 20 A -58 ) LEU( 20 A -57 ) LYS( 20 A -56 ) ASP( 20 A -55 ) LEU( 20 A -54 ) LEU( 20 A -53 ) LYS( 20 A -52 ) ASP( 20 A -51 ) MET( 20 A -50 ) ASN( 20 A -49 ) GLN( 20 A -48 ) SER( 20 A -47 ) SER( 20 A -46 ) LEU( 20 A -45 ) ALA( 20 A -44 ) LYS( 20 A -43 ) GLU( 20 A -42 ) CYS( 20 A -41 ) PRO( 20 A -40 ) LEU( 20 A -39 ) SER( 20 A -38 ) GLN( 20 A -37 ) SER( 20 A -36 ) MET( 20 A -35 ) ILE( 20 A -34 ) SER( 20 A -33 ) SER( 20 A -32 ) ILE( 20 A -31 ) VAL( 20 A -30 ) ASN( 20 A -29 ) SER( 20 A -28 ) THR( 20 A -27 ) TYR( 20 A -26 ) TYR( 20 A -25 ) ALA( 20 A -24 ) ASN( 20 A -23 ) VAL( 20 A -22 ) SER( 20 A -21 ) ALA( 20 A -20 ) ALA( 20 A -19 ) LYS( 20 A -18 ) CYS( 20 A -17 ) GLN( 20 A -16 ) GLU( 20 A -15 ) PHE( 20 A -14 ) GLY( 20 A -13 ) ARG( 20 A -12 ) TRP( 20 A -11 ) TYR( 20 A -10 ) LYS( 20 A -9 ) HIS( 20 A -8 ) PHE( 20 A -7 ) LYS( 20 A -6 ) LYS( 20 A -5 ) THR( 20 A -4 ) LYS( 20 A -3 ) ASP( 20 A -2 ) MET( 20 A -1 ) MET( 20 A 0 ) PDB Chain_ID: A 1 15 SEQRES: MET GLY HIS HIS HIS HIS HIS HIS SER HIS MET LEU PRO PRO GLU COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 16 30 SEQRES: GLN TRP SER HIS THR THR VAL ARG ASN ALA LEU LYS ASP LEU LEU COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 31 45 SEQRES: LYS ASP MET ASN GLN SER SER LEU ALA LYS GLU CYS PRO LEU SER COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 46 60 SEQRES: GLN SER MET ILE SER SER ILE VAL ASN SER THR TYR TYR ALA ASN COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 61 75 SEQRES: VAL SER ALA ALA LYS CYS GLN GLU PHE GLY ARG TRP TYR LYS HIS COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 76 90 SEQRES: PHE LYS LYS THR LYS ASP MET MET MET GLY HIS HIS HIS HIS HIS COORDS: ... ... ... ... ... ... ... ... MET GLY HIS HIS HIS HIS HIS 1 7 91 105 SEQRES: HIS SER HIS MET LEU PRO PRO GLU GLN TRP SER HIS THR THR VAL COORDS: HIS SER HIS MET LEU PRO PRO GLU GLN TRP SER HIS THR THR VAL 8 22 106 120 SEQRES: ARG ASN ALA LEU LYS ASP LEU LEU LYS ASP MET ASN GLN SER SER COORDS: ARG ASN ALA LEU LYS ASP LEU LEU LYS ASP MET ASN GLN SER SER 23 37 121 135 SEQRES: LEU ALA LYS GLU CYS PRO LEU SER GLN SER MET ILE SER SER ILE COORDS: LEU ALA LYS GLU CYS PRO LEU SER GLN SER MET ILE SER SER ILE 38 52 136 150 SEQRES: VAL ASN SER THR TYR TYR ALA ASN VAL SER ALA ALA LYS CYS GLN COORDS: VAL ASN SER THR TYR TYR ALA ASN VAL SER ALA ALA LYS CYS GLN 53 67 151 165 SEQRES: GLU PHE GLY ARG TRP TYR LYS HIS PHE LYS LYS THR LYS ASP MET COORDS: GLU PHE GLY ARG TRP TYR LYS HIS PHE LYS LYS THR LYS ASP MET 68 82 166 SEQRES: MET COORDS: MET 83 ==> The following residues have missing atoms: RES MOD#C SEQ ATOMS GLU( 1 A 15) HE2 ASP( 1 A 28) HD2 ASP( 1 A 32) HD2 GLU( 1 A 41) HE2 GLU( 1 A 68) HE2 ASP( 1 A 81) HD2 GLU( 2 A 15) HE2 ASP( 2 A 28) HD2 ASP( 2 A 32) HD2 GLU( 2 A 41) HE2 GLU( 2 A 68) HE2 ASP( 2 A 81) HD2 GLU( 3 A 15) HE2 ASP( 3 A 28) HD2 ASP( 3 A 32) HD2 GLU( 3 A 41) HE2 GLU( 3 A 68) HE2 ASP( 3 A 81) HD2 GLU( 4 A 15) HE2 ASP( 4 A 28) HD2 ASP( 4 A 32) HD2 GLU( 4 A 41) HE2 GLU( 4 A 68) HE2 ASP( 4 A 81) HD2 GLU( 5 A 15) HE2 ASP( 5 A 28) HD2 ASP( 5 A 32) HD2 GLU( 5 A 41) HE2 GLU( 5 A 68) HE2 ASP( 5 A 81) HD2 GLU( 6 A 15) HE2 ASP( 6 A 28) HD2 ASP( 6 A 32) HD2 GLU( 6 A 41) HE2 GLU( 6 A 68) HE2 ASP( 6 A 81) HD2 GLU( 7 A 15) HE2 ASP( 7 A 28) HD2 ASP( 7 A 32) HD2 GLU( 7 A 41) HE2 GLU( 7 A 68) HE2 ASP( 7 A 81) HD2 GLU( 8 A 15) HE2 ASP( 8 A 28) HD2 ASP( 8 A 32) HD2 GLU( 8 A 41) HE2 GLU( 8 A 68) HE2 ASP( 8 A 81) HD2 GLU( 9 A 15) HE2 ASP( 9 A 28) HD2 ASP( 9 A 32) HD2 GLU( 9 A 41) HE2 GLU( 9 A 68) HE2 ASP( 9 A 81) HD2 GLU( 10 A 15) HE2 ASP( 10 A 28) HD2 ASP( 10 A 32) HD2 GLU( 10 A 41) HE2 GLU( 10 A 68) HE2 ASP( 10 A 81) HD2 GLU( 11 A 15) HE2 ASP( 11 A 28) HD2 ASP( 11 A 32) HD2 GLU( 11 A 41) HE2 GLU( 11 A 68) HE2 ASP( 11 A 81) HD2 GLU( 12 A 15) HE2 ASP( 12 A 28) HD2 ASP( 12 A 32) HD2 GLU( 12 A 41) HE2 GLU( 12 A 68) HE2 ASP( 12 A 81) HD2 GLU( 13 A 15) HE2 ASP( 13 A 28) HD2 ASP( 13 A 32) HD2 GLU( 13 A 41) HE2 GLU( 13 A 68) HE2 ASP( 13 A 81) HD2 GLU( 14 A 15) HE2 ASP( 14 A 28) HD2 ASP( 14 A 32) HD2 GLU( 14 A 41) HE2 GLU( 14 A 68) HE2 ASP( 14 A 81) HD2 GLU( 15 A 15) HE2 ASP( 15 A 28) HD2 ASP( 15 A 32) HD2 GLU( 15 A 41) HE2 GLU( 15 A 68) HE2 ASP( 15 A 81) HD2 GLU( 16 A 15) HE2 ASP( 16 A 28) HD2 ASP( 16 A 32) HD2 GLU( 16 A 41) HE2 GLU( 16 A 68) HE2 ASP( 16 A 81) HD2 GLU( 17 A 15) HE2 ASP( 17 A 28) HD2 ASP( 17 A 32) HD2 GLU( 17 A 41) HE2 GLU( 17 A 68) HE2 ASP( 17 A 81) HD2 GLU( 18 A 15) HE2 ASP( 18 A 28) HD2 ASP( 18 A 32) HD2 GLU( 18 A 41) HE2 GLU( 18 A 68) HE2 ASP( 18 A 81) HD2 GLU( 19 A 15) HE2 ASP( 19 A 28) HD2 ASP( 19 A 32) HD2 GLU( 19 A 41) HE2 GLU( 19 A 68) HE2 ASP( 19 A 81) HD2 GLU( 20 A 15) HE2 ASP( 20 A 28) HD2 ASP( 20 A 32) HD2 GLU( 20 A 41) HE2 GLU( 20 A 68) HE2 ASP( 20 A 81) HD2 ==> The following residues have extra atoms: RES MOD#C SEQ ATOMS MET( 1 A 83) O2 MET( 2 A 83) O2 MET( 3 A 83) O2 MET( 4 A 83) O2 MET( 5 A 83) O2 MET( 6 A 83) O2 MET( 7 A 83) O2 MET( 8 A 83) O2 MET( 9 A 83) O2 MET( 10 A 83) O2 MET( 11 A 83) O2 MET( 12 A 83) O2 MET( 13 A 83) O2 MET( 14 A 83) O2 MET( 15 A 83) O2 MET( 16 A 83) O2 MET( 17 A 83) O2 MET( 18 A 83) O2 MET( 19 A 83) O2 MET( 20 A 83) O2 CHECK TERMINAL ATOMS -------------------- Terminal atom(s) showed in middle of sequence will be deleted: 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A