May. 9, 22:00:50 2013 [ Text modified to reflect that this was run under PSVS - Aneerban Bhattacharya: Dec 2005 ] The following checks were made on : ----------------------------------------- CLOSE CONTACTS ==> Distances smaller than 2.2 Angstroms are considered as close contacts for heavy atoms, 1.6 Angstroms for hydrogens. Chain Atom Res Seq Chain Atom Res Seq Mol_ID Distance ------------------------------------------------------------------------- A 3HZ LYS 6 - A 2HB LEU 8 7 Dist = 1.39 A 2HE2 GLN 53 - A 2HD2 LEU 56 12 Dist = 1.46 A 1HB ASP 102 - A 1HB GLN 108 15 Dist = 1.47 A 2HE LYS 6 - A HE2 PHE 22 4 Dist = 1.48 A 1HE LYS 6 - A HE2 PHE 22 19 Dist = 1.51 A 2HB ALA 74 - A HA ARG 80 12 Dist = 1.51 A HA ALA 74 - A HA ARG 80 2 Dist = 1.52 A 2HB ASP 102 - A 2HE2 GLN 108 7 Dist = 1.54 A 2HB TYR 5 - A 3HD2 LEU 58 14 Dist = 1.54 A 1HB ALA 46 - A 1HG PRO 107 16 Dist = 1.54 A 2HE LYS 6 - A HE2 PHE 22 14 Dist = 1.56 A 3HB ALA 74 - A 1HH1 ARG 80 20 Dist = 1.59 A 1HD1 ILE 34 - A 2HD1 LEU 88 16 Dist = 1.59 A 2HG2 VAL 61 - A 2HG1 VAL 93 4 Dist = 1.59 DISTANCES AND ANGLES We have checked your intra and intermolecular distances and angles with the procedures currently in place at PDB: ==> Bond and angle checks are performed by first computing the average rms error for all bonds and angles relative to standard values for nucleotide units [L. Clowney et al., Geometric Parameters in Nucleic Acids: Nitrogenous Bases, J.Am.Chem.Soc. 1996, 118, 509-518; A. Gelbin et al., Geometric Parameters in Nucleic Acids: Sugar and Phosphate Constituents, J.Am.Chem.Soc. 1996, 118, 519-529] and amino acid units [R.A. Engh and R. Huber, Accurate Bond and Angle Parameters for X-ray protein structure refinement, Acta Crystallogr. 1991, A47, 392-400]. Any bond or angle which deviates from the dictionary values by more than six times this computed rms error is identified as an outlier. *** Covalent Bond Lengths: The RMS deviation for covalent bonds relative to the standard dictionary is 0.009 Angstroms All covalent bonds lie within a 6.0*RMSD range about the standard dictionary values. *** Covalent Angle Values: The RMS deviation for covalent angles relative to the standard dictionary is 0.6 degrees. The following table contains a list of the covalent bond angles greater than 6.0*RMSD. Deviation Residue Chain Sequence Model AT1 - AT2 - AT3 Bond Dictionary Name ID Number Angle Value -------------------------------------------------------------------------------- 4.1 ALA A 63 1 N - CA - C 115.3 111.2 4.3 PRO A 107 6 N - CA - C 116.1 111.8 4.2 GLN A 108 6 N - CA - C 115.4 111.2 4.6 VAL A 106 12 N - CA - C 115.8 111.2 4.4 VAL A 106 12 CA - C - N 121.3 116.9 4.0 ALA A 63 17 N - CA - C 115.2 111.2 3.6 ASP A 69 17 N - CA - C 114.8 111.2 4.6 PRO A 65 18 N - CA - C 116.4 111.8 TORSION ANGLES The torsion angle distributions have been checked. The postscript file of the conformation rings showing the torsion angle distributions will be sent in a separate E-mail message. CHIRALITY The chirality has been checked. O1P, O2P, and hydrogen atoms which do not follow the convention defined in the IUBMB (Liebecq, C. Compendium of Biochemical Nomenclature and Related Documents, 2nd ed.; Portland Press: London and Chapel Hill, 1992) and IUPAC nomenclature (J.L. Markley, A. Bax, Y. Arata, C.W. Hilbers, R. Kaptein, B.D. Sykes, P.E. Wright and K. Wüthrich, Recommendations for the Presentation of NMR Structures of Proteins and Nucleic Acids, Pure & Appl. Chem., Vol. 70, pp. 117-142, 1998) have been standardized. Any other stereochemical violations are listed below. E/Z NOMENCLATURE E/Z nomenclature of hydrogens and/or nitrogens on Arg, Asn or Gln residues needs to be corrected to conform with the standard for E/Z orientation presented in [J.L. Markley, et al., Recommendations for the Presentation of NMR Structures of Proteins and Nucleic Acids, Pure & Appl. Chem., 1998, 70, 117-142]. Model Chain Residue Residue Atom Name Original Name Number Atom Name ----- ----- ------- ------- -------- --------- 1 A GLN 19 1HE2 1 A GLN 19 2HE2 1 A GLN 41 1HE2 1 A GLN 41 2HE2 1 A GLN 43 1HE2 1 A GLN 43 2HE2 1 A GLN 53 1HE2 1 A GLN 53 2HE2 1 A ASN 55 1HD2 1 A ASN 55 2HD2 1 A GLN 108 1HE2 1 A GLN 108 2HE2 2 A GLN 19 1HE2 2 A GLN 19 2HE2 2 A GLN 41 1HE2 2 A GLN 41 2HE2 2 A GLN 43 1HE2 2 A GLN 43 2HE2 2 A GLN 53 1HE2 2 A GLN 53 2HE2 2 A ASN 55 1HD2 2 A ASN 55 2HD2 2 A GLN 108 1HE2 2 A GLN 108 2HE2 3 A GLN 19 1HE2 3 A GLN 19 2HE2 3 A GLN 41 1HE2 3 A GLN 41 2HE2 3 A GLN 43 1HE2 3 A GLN 43 2HE2 3 A GLN 53 1HE2 3 A GLN 53 2HE2 3 A ASN 55 1HD2 3 A ASN 55 2HD2 3 A GLN 108 1HE2 3 A GLN 108 2HE2 4 A GLN 19 1HE2 4 A GLN 19 2HE2 4 A GLN 41 1HE2 4 A GLN 41 2HE2 4 A GLN 43 1HE2 4 A GLN 43 2HE2 4 A GLN 53 1HE2 4 A GLN 53 2HE2 4 A ASN 55 1HD2 4 A ASN 55 2HD2 4 A GLN 108 1HE2 4 A GLN 108 2HE2 5 A GLN 19 1HE2 5 A GLN 19 2HE2 5 A GLN 41 1HE2 5 A GLN 41 2HE2 5 A GLN 43 1HE2 5 A GLN 43 2HE2 5 A GLN 53 1HE2 5 A GLN 53 2HE2 5 A ASN 55 1HD2 5 A ASN 55 2HD2 5 A GLN 108 1HE2 5 A GLN 108 2HE2 6 A GLN 19 1HE2 6 A GLN 19 2HE2 6 A GLN 41 1HE2 6 A GLN 41 2HE2 6 A GLN 43 1HE2 6 A GLN 43 2HE2 6 A GLN 53 1HE2 6 A GLN 53 2HE2 6 A ASN 55 1HD2 6 A ASN 55 2HD2 6 A GLN 108 1HE2 6 A GLN 108 2HE2 7 A GLN 19 1HE2 7 A GLN 19 2HE2 7 A GLN 41 1HE2 7 A GLN 41 2HE2 7 A GLN 43 1HE2 7 A GLN 43 2HE2 7 A GLN 53 1HE2 7 A GLN 53 2HE2 7 A ASN 55 1HD2 7 A ASN 55 2HD2 7 A GLN 108 1HE2 7 A GLN 108 2HE2 8 A GLN 19 1HE2 8 A GLN 19 2HE2 8 A GLN 41 1HE2 8 A GLN 41 2HE2 8 A GLN 43 1HE2 8 A GLN 43 2HE2 8 A GLN 53 1HE2 8 A GLN 53 2HE2 8 A ASN 55 1HD2 8 A ASN 55 2HD2 8 A GLN 108 1HE2 8 A GLN 108 2HE2 9 A GLN 19 1HE2 9 A GLN 19 2HE2 9 A GLN 41 1HE2 9 A GLN 41 2HE2 9 A GLN 43 1HE2 9 A GLN 43 2HE2 9 A GLN 53 1HE2 9 A GLN 53 2HE2 9 A ASN 55 1HD2 9 A ASN 55 2HD2 9 A GLN 108 1HE2 9 A GLN 108 2HE2 10 A GLN 19 1HE2 10 A GLN 19 2HE2 10 A GLN 41 1HE2 10 A GLN 41 2HE2 10 A GLN 43 1HE2 10 A GLN 43 2HE2 10 A GLN 53 1HE2 10 A GLN 53 2HE2 10 A ASN 55 1HD2 10 A ASN 55 2HD2 10 A GLN 108 1HE2 10 A GLN 108 2HE2 11 A GLN 19 1HE2 11 A GLN 19 2HE2 11 A GLN 41 1HE2 11 A GLN 41 2HE2 11 A GLN 43 1HE2 11 A GLN 43 2HE2 11 A GLN 53 1HE2 11 A GLN 53 2HE2 11 A ASN 55 1HD2 11 A ASN 55 2HD2 11 A GLN 108 1HE2 11 A GLN 108 2HE2 12 A GLN 19 1HE2 12 A GLN 19 2HE2 12 A GLN 41 1HE2 12 A GLN 41 2HE2 12 A GLN 43 1HE2 12 A GLN 43 2HE2 12 A GLN 53 1HE2 12 A GLN 53 2HE2 12 A ASN 55 1HD2 12 A ASN 55 2HD2 12 A GLN 108 1HE2 12 A GLN 108 2HE2 13 A GLN 19 1HE2 13 A GLN 19 2HE2 13 A GLN 41 1HE2 13 A GLN 41 2HE2 13 A GLN 43 1HE2 13 A GLN 43 2HE2 13 A GLN 53 1HE2 13 A GLN 53 2HE2 13 A ASN 55 1HD2 13 A ASN 55 2HD2 13 A GLN 108 1HE2 13 A GLN 108 2HE2 14 A GLN 19 1HE2 14 A GLN 19 2HE2 14 A GLN 41 1HE2 14 A GLN 41 2HE2 14 A GLN 43 1HE2 14 A GLN 43 2HE2 14 A GLN 53 1HE2 14 A GLN 53 2HE2 14 A ASN 55 1HD2 14 A ASN 55 2HD2 14 A GLN 108 1HE2 14 A GLN 108 2HE2 15 A GLN 19 1HE2 15 A GLN 19 2HE2 15 A GLN 41 1HE2 15 A GLN 41 2HE2 15 A GLN 43 1HE2 15 A GLN 43 2HE2 15 A GLN 53 1HE2 15 A GLN 53 2HE2 15 A ASN 55 1HD2 15 A ASN 55 2HD2 15 A GLN 108 1HE2 15 A GLN 108 2HE2 16 A GLN 19 1HE2 16 A GLN 19 2HE2 16 A GLN 41 1HE2 16 A GLN 41 2HE2 16 A GLN 43 1HE2 16 A GLN 43 2HE2 16 A GLN 53 1HE2 16 A GLN 53 2HE2 16 A ASN 55 1HD2 16 A ASN 55 2HD2 16 A GLN 108 1HE2 16 A GLN 108 2HE2 17 A GLN 19 1HE2 17 A GLN 19 2HE2 17 A GLN 41 1HE2 17 A GLN 41 2HE2 17 A GLN 43 1HE2 17 A GLN 43 2HE2 17 A GLN 53 1HE2 17 A GLN 53 2HE2 17 A ASN 55 1HD2 17 A ASN 55 2HD2 17 A GLN 108 1HE2 17 A GLN 108 2HE2 18 A GLN 19 1HE2 18 A GLN 19 2HE2 18 A GLN 41 1HE2 18 A GLN 41 2HE2 18 A GLN 43 1HE2 18 A GLN 43 2HE2 18 A GLN 53 1HE2 18 A GLN 53 2HE2 18 A ASN 55 1HD2 18 A ASN 55 2HD2 18 A GLN 108 1HE2 18 A GLN 108 2HE2 19 A GLN 19 1HE2 19 A GLN 19 2HE2 19 A GLN 41 1HE2 19 A GLN 41 2HE2 19 A GLN 43 1HE2 19 A GLN 43 2HE2 19 A GLN 53 1HE2 19 A GLN 53 2HE2 19 A ASN 55 1HD2 19 A ASN 55 2HD2 19 A GLN 108 1HE2 19 A GLN 108 2HE2 20 A GLN 19 1HE2 20 A GLN 19 2HE2 20 A GLN 41 1HE2 20 A GLN 41 2HE2 20 A GLN 43 1HE2 20 A GLN 43 2HE2 20 A GLN 53 1HE2 20 A GLN 53 2HE2 20 A ASN 55 1HD2 20 A ASN 55 2HD2 20 A GLN 108 1HE2 20 A GLN 108 2HE2 OTHER IMPORTANT ISSUES ==> The following residues are missing: (Note: The SEQ number starts from 1 for each chain according to SEQRES sequence record.) RES MOD#C SEQ MET( 1 A-121 ) THR( 1 A-120 ) LEU( 1 A-119 ) ILE( 1 A-118 ) TYR( 1 A-117 ) LYS( 1 A-116 ) ILE( 1 A-115 ) LEU( 1 A-114 ) SER( 1 A-113 ) ARG( 1 A-112 ) ALA( 1 A-111 ) GLU( 1 A-110 ) TRP( 1 A-109 ) ASP( 1 A-108 ) ALA( 1 A-107 ) ALA( 1 A-106 ) LYS( 1 A-105 ) ALA( 1 A-104 ) GLN( 1 A-103 ) GLY( 1 A-102 ) ARG( 1 A-101 ) PHE( 1 A-100 ) GLU( 1 A -99 ) GLY( 1 A -98 ) SER( 1 A -97 ) ALA( 1 A -96 ) VAL( 1 A -95 ) ASP( 1 A -94 ) LEU( 1 A -93 ) ALA( 1 A -92 ) ASP( 1 A -91 ) GLY( 1 A -90 ) PHE( 1 A -89 ) ILE( 1 A -88 ) HIS( 1 A -87 ) LEU( 1 A -86 ) SER( 1 A -85 ) ALA( 1 A -84 ) GLY( 1 A -83 ) GLU( 1 A -82 ) GLN( 1 A -81 ) ALA( 1 A -80 ) GLN( 1 A -79 ) GLU( 1 A -78 ) THR( 1 A -77 ) ALA( 1 A -76 ) ALA( 1 A -75 ) LYS( 1 A -74 ) TRP( 1 A -73 ) PHE( 1 A -72 ) ARG( 1 A -71 ) GLY( 1 A -70 ) GLN( 1 A -69 ) ALA( 1 A -68 ) ASN( 1 A -67 ) LEU( 1 A -66 ) VAL( 1 A -65 ) LEU( 1 A -64 ) LEU( 1 A -63 ) ALA( 1 A -62 ) VAL( 1 A -61 ) GLU( 1 A -60 ) ALA( 1 A -59 ) GLU( 1 A -58 ) PRO( 1 A -57 ) LEU( 1 A -56 ) GLY( 1 A -55 ) GLU( 1 A -54 ) ASP( 1 A -53 ) LEU( 1 A -52 ) LYS( 1 A -51 ) TRP( 1 A -50 ) GLU( 1 A -49 ) ALA( 1 A -48 ) SER( 1 A -47 ) ARG( 1 A -46 ) GLY( 1 A -45 ) GLY( 1 A -44 ) ALA( 1 A -43 ) ARG( 1 A -42 ) PHE( 1 A -41 ) PRO( 1 A -40 ) HIS( 1 A -39 ) LEU( 1 A -38 ) TYR( 1 A -37 ) ARG( 1 A -36 ) PRO( 1 A -35 ) LEU( 1 A -34 ) LEU( 1 A -33 ) VAL( 1 A -32 ) SER( 1 A -31 ) GLU( 1 A -30 ) VAL( 1 A -29 ) THR( 1 A -28 ) ARG( 1 A -27 ) GLU( 1 A -26 ) ALA( 1 A -25 ) ASP( 1 A -24 ) LEU( 1 A -23 ) ASP( 1 A -22 ) LEU( 1 A -21 ) ASP( 1 A -20 ) ALA( 1 A -19 ) ASP( 1 A -18 ) GLY( 1 A -17 ) VAL( 1 A -16 ) PRO( 1 A -15 ) GLN( 1 A -14 ) LEU( 1 A -13 ) GLY( 1 A -12 ) ASP( 1 A -11 ) HIS( 1 A -10 ) LEU( 1 A -9 ) ALA( 1 A -8 ) LEU( 1 A -7 ) GLU( 1 A -6 ) HIS( 1 A -5 ) HIS( 1 A -4 ) HIS( 1 A -3 ) HIS( 1 A -2 ) HIS( 1 A -1 ) HIS( 1 A 0 ) MET( 2 A-121 ) THR( 2 A-120 ) LEU( 2 A-119 ) ILE( 2 A-118 ) TYR( 2 A-117 ) LYS( 2 A-116 ) ILE( 2 A-115 ) LEU( 2 A-114 ) SER( 2 A-113 ) ARG( 2 A-112 ) ALA( 2 A-111 ) GLU( 2 A-110 ) TRP( 2 A-109 ) ASP( 2 A-108 ) ALA( 2 A-107 ) ALA( 2 A-106 ) LYS( 2 A-105 ) ALA( 2 A-104 ) GLN( 2 A-103 ) GLY( 2 A-102 ) ARG( 2 A-101 ) PHE( 2 A-100 ) GLU( 2 A -99 ) GLY( 2 A -98 ) SER( 2 A -97 ) ALA( 2 A -96 ) VAL( 2 A -95 ) ASP( 2 A -94 ) LEU( 2 A -93 ) ALA( 2 A -92 ) ASP( 2 A -91 ) GLY( 2 A -90 ) PHE( 2 A -89 ) ILE( 2 A -88 ) HIS( 2 A -87 ) LEU( 2 A -86 ) SER( 2 A -85 ) ALA( 2 A -84 ) GLY( 2 A -83 ) GLU( 2 A -82 ) GLN( 2 A -81 ) ALA( 2 A -80 ) GLN( 2 A -79 ) GLU( 2 A -78 ) THR( 2 A -77 ) ALA( 2 A -76 ) ALA( 2 A -75 ) LYS( 2 A -74 ) TRP( 2 A -73 ) PHE( 2 A -72 ) ARG( 2 A -71 ) GLY( 2 A -70 ) GLN( 2 A -69 ) ALA( 2 A -68 ) ASN( 2 A -67 ) LEU( 2 A -66 ) VAL( 2 A -65 ) LEU( 2 A -64 ) LEU( 2 A -63 ) ALA( 2 A -62 ) VAL( 2 A -61 ) GLU( 2 A -60 ) ALA( 2 A -59 ) GLU( 2 A -58 ) PRO( 2 A -57 ) LEU( 2 A -56 ) GLY( 2 A -55 ) GLU( 2 A -54 ) ASP( 2 A -53 ) LEU( 2 A -52 ) LYS( 2 A -51 ) TRP( 2 A -50 ) GLU( 2 A -49 ) ALA( 2 A -48 ) SER( 2 A -47 ) ARG( 2 A -46 ) GLY( 2 A -45 ) GLY( 2 A -44 ) ALA( 2 A -43 ) ARG( 2 A -42 ) PHE( 2 A -41 ) PRO( 2 A -40 ) HIS( 2 A -39 ) LEU( 2 A -38 ) TYR( 2 A -37 ) ARG( 2 A -36 ) PRO( 2 A -35 ) LEU( 2 A -34 ) LEU( 2 A -33 ) VAL( 2 A -32 ) SER( 2 A -31 ) GLU( 2 A -30 ) VAL( 2 A -29 ) THR( 2 A -28 ) ARG( 2 A -27 ) GLU( 2 A -26 ) ALA( 2 A -25 ) ASP( 2 A -24 ) LEU( 2 A -23 ) ASP( 2 A -22 ) LEU( 2 A -21 ) ASP( 2 A -20 ) ALA( 2 A -19 ) ASP( 2 A -18 ) GLY( 2 A -17 ) VAL( 2 A -16 ) PRO( 2 A -15 ) GLN( 2 A -14 ) LEU( 2 A -13 ) GLY( 2 A -12 ) ASP( 2 A -11 ) HIS( 2 A -10 ) LEU( 2 A -9 ) ALA( 2 A -8 ) LEU( 2 A -7 ) GLU( 2 A -6 ) HIS( 2 A -5 ) HIS( 2 A -4 ) HIS( 2 A -3 ) HIS( 2 A -2 ) HIS( 2 A -1 ) HIS( 2 A 0 ) MET( 3 A-121 ) THR( 3 A-120 ) LEU( 3 A-119 ) ILE( 3 A-118 ) TYR( 3 A-117 ) LYS( 3 A-116 ) ILE( 3 A-115 ) LEU( 3 A-114 ) SER( 3 A-113 ) ARG( 3 A-112 ) ALA( 3 A-111 ) GLU( 3 A-110 ) TRP( 3 A-109 ) ASP( 3 A-108 ) ALA( 3 A-107 ) ALA( 3 A-106 ) LYS( 3 A-105 ) ALA( 3 A-104 ) GLN( 3 A-103 ) GLY( 3 A-102 ) ARG( 3 A-101 ) PHE( 3 A-100 ) GLU( 3 A -99 ) GLY( 3 A -98 ) SER( 3 A -97 ) ALA( 3 A -96 ) VAL( 3 A -95 ) ASP( 3 A -94 ) LEU( 3 A -93 ) ALA( 3 A -92 ) ASP( 3 A -91 ) GLY( 3 A -90 ) PHE( 3 A -89 ) ILE( 3 A -88 ) HIS( 3 A -87 ) LEU( 3 A -86 ) SER( 3 A -85 ) ALA( 3 A -84 ) GLY( 3 A -83 ) GLU( 3 A -82 ) GLN( 3 A -81 ) ALA( 3 A -80 ) GLN( 3 A -79 ) GLU( 3 A -78 ) THR( 3 A -77 ) ALA( 3 A -76 ) ALA( 3 A -75 ) LYS( 3 A -74 ) TRP( 3 A -73 ) PHE( 3 A -72 ) ARG( 3 A -71 ) GLY( 3 A -70 ) GLN( 3 A -69 ) ALA( 3 A -68 ) ASN( 3 A -67 ) LEU( 3 A -66 ) VAL( 3 A -65 ) LEU( 3 A -64 ) LEU( 3 A -63 ) ALA( 3 A -62 ) VAL( 3 A -61 ) GLU( 3 A -60 ) ALA( 3 A -59 ) GLU( 3 A -58 ) PRO( 3 A -57 ) LEU( 3 A -56 ) GLY( 3 A -55 ) GLU( 3 A -54 ) ASP( 3 A -53 ) LEU( 3 A -52 ) LYS( 3 A -51 ) TRP( 3 A -50 ) GLU( 3 A -49 ) ALA( 3 A -48 ) SER( 3 A -47 ) ARG( 3 A -46 ) GLY( 3 A -45 ) GLY( 3 A -44 ) ALA( 3 A -43 ) ARG( 3 A -42 ) PHE( 3 A -41 ) PRO( 3 A -40 ) HIS( 3 A -39 ) LEU( 3 A -38 ) TYR( 3 A -37 ) ARG( 3 A -36 ) PRO( 3 A -35 ) LEU( 3 A -34 ) LEU( 3 A -33 ) VAL( 3 A -32 ) SER( 3 A -31 ) GLU( 3 A -30 ) VAL( 3 A -29 ) THR( 3 A -28 ) ARG( 3 A -27 ) GLU( 3 A -26 ) ALA( 3 A -25 ) ASP( 3 A -24 ) LEU( 3 A -23 ) ASP( 3 A -22 ) LEU( 3 A -21 ) ASP( 3 A -20 ) ALA( 3 A -19 ) ASP( 3 A -18 ) GLY( 3 A -17 ) VAL( 3 A -16 ) PRO( 3 A -15 ) GLN( 3 A -14 ) LEU( 3 A -13 ) GLY( 3 A -12 ) ASP( 3 A -11 ) HIS( 3 A -10 ) LEU( 3 A -9 ) ALA( 3 A -8 ) LEU( 3 A -7 ) GLU( 3 A -6 ) HIS( 3 A -5 ) HIS( 3 A -4 ) HIS( 3 A -3 ) HIS( 3 A -2 ) HIS( 3 A -1 ) HIS( 3 A 0 ) MET( 4 A-121 ) THR( 4 A-120 ) LEU( 4 A-119 ) ILE( 4 A-118 ) TYR( 4 A-117 ) LYS( 4 A-116 ) ILE( 4 A-115 ) LEU( 4 A-114 ) SER( 4 A-113 ) ARG( 4 A-112 ) ALA( 4 A-111 ) GLU( 4 A-110 ) TRP( 4 A-109 ) ASP( 4 A-108 ) ALA( 4 A-107 ) ALA( 4 A-106 ) LYS( 4 A-105 ) ALA( 4 A-104 ) GLN( 4 A-103 ) GLY( 4 A-102 ) ARG( 4 A-101 ) PHE( 4 A-100 ) GLU( 4 A -99 ) GLY( 4 A -98 ) SER( 4 A -97 ) ALA( 4 A -96 ) VAL( 4 A -95 ) ASP( 4 A -94 ) LEU( 4 A -93 ) ALA( 4 A -92 ) ASP( 4 A -91 ) GLY( 4 A -90 ) PHE( 4 A -89 ) ILE( 4 A -88 ) HIS( 4 A -87 ) LEU( 4 A -86 ) SER( 4 A -85 ) ALA( 4 A -84 ) GLY( 4 A -83 ) GLU( 4 A -82 ) GLN( 4 A -81 ) ALA( 4 A -80 ) GLN( 4 A -79 ) GLU( 4 A -78 ) THR( 4 A -77 ) ALA( 4 A -76 ) ALA( 4 A -75 ) LYS( 4 A -74 ) TRP( 4 A -73 ) PHE( 4 A -72 ) ARG( 4 A -71 ) GLY( 4 A -70 ) GLN( 4 A -69 ) ALA( 4 A -68 ) ASN( 4 A -67 ) LEU( 4 A -66 ) VAL( 4 A -65 ) LEU( 4 A -64 ) LEU( 4 A -63 ) ALA( 4 A -62 ) VAL( 4 A -61 ) GLU( 4 A -60 ) ALA( 4 A -59 ) GLU( 4 A -58 ) PRO( 4 A -57 ) LEU( 4 A -56 ) GLY( 4 A -55 ) GLU( 4 A -54 ) ASP( 4 A -53 ) LEU( 4 A -52 ) LYS( 4 A -51 ) TRP( 4 A -50 ) GLU( 4 A -49 ) ALA( 4 A -48 ) SER( 4 A -47 ) ARG( 4 A -46 ) GLY( 4 A -45 ) GLY( 4 A -44 ) ALA( 4 A -43 ) ARG( 4 A -42 ) PHE( 4 A -41 ) PRO( 4 A -40 ) HIS( 4 A -39 ) LEU( 4 A -38 ) TYR( 4 A -37 ) ARG( 4 A -36 ) PRO( 4 A -35 ) LEU( 4 A -34 ) LEU( 4 A -33 ) VAL( 4 A -32 ) SER( 4 A -31 ) GLU( 4 A -30 ) VAL( 4 A -29 ) THR( 4 A -28 ) ARG( 4 A -27 ) GLU( 4 A -26 ) ALA( 4 A -25 ) ASP( 4 A -24 ) LEU( 4 A -23 ) ASP( 4 A -22 ) LEU( 4 A -21 ) ASP( 4 A -20 ) ALA( 4 A -19 ) ASP( 4 A -18 ) GLY( 4 A -17 ) VAL( 4 A -16 ) PRO( 4 A -15 ) GLN( 4 A -14 ) LEU( 4 A -13 ) GLY( 4 A -12 ) ASP( 4 A -11 ) HIS( 4 A -10 ) LEU( 4 A -9 ) ALA( 4 A -8 ) LEU( 4 A -7 ) GLU( 4 A -6 ) HIS( 4 A -5 ) HIS( 4 A -4 ) HIS( 4 A -3 ) HIS( 4 A -2 ) HIS( 4 A -1 ) HIS( 4 A 0 ) MET( 5 A-121 ) THR( 5 A-120 ) LEU( 5 A-119 ) ILE( 5 A-118 ) TYR( 5 A-117 ) LYS( 5 A-116 ) ILE( 5 A-115 ) LEU( 5 A-114 ) SER( 5 A-113 ) ARG( 5 A-112 ) ALA( 5 A-111 ) GLU( 5 A-110 ) TRP( 5 A-109 ) ASP( 5 A-108 ) ALA( 5 A-107 ) ALA( 5 A-106 ) LYS( 5 A-105 ) ALA( 5 A-104 ) GLN( 5 A-103 ) GLY( 5 A-102 ) ARG( 5 A-101 ) PHE( 5 A-100 ) GLU( 5 A -99 ) GLY( 5 A -98 ) SER( 5 A -97 ) ALA( 5 A -96 ) VAL( 5 A -95 ) ASP( 5 A -94 ) LEU( 5 A -93 ) ALA( 5 A -92 ) ASP( 5 A -91 ) GLY( 5 A -90 ) PHE( 5 A -89 ) ILE( 5 A -88 ) HIS( 5 A -87 ) LEU( 5 A -86 ) SER( 5 A -85 ) ALA( 5 A -84 ) GLY( 5 A -83 ) GLU( 5 A -82 ) GLN( 5 A -81 ) ALA( 5 A -80 ) GLN( 5 A -79 ) GLU( 5 A -78 ) THR( 5 A -77 ) ALA( 5 A -76 ) ALA( 5 A -75 ) LYS( 5 A -74 ) TRP( 5 A -73 ) PHE( 5 A -72 ) ARG( 5 A -71 ) GLY( 5 A -70 ) GLN( 5 A -69 ) ALA( 5 A -68 ) ASN( 5 A -67 ) LEU( 5 A -66 ) VAL( 5 A -65 ) LEU( 5 A -64 ) LEU( 5 A -63 ) ALA( 5 A -62 ) VAL( 5 A -61 ) GLU( 5 A -60 ) ALA( 5 A -59 ) GLU( 5 A -58 ) PRO( 5 A -57 ) LEU( 5 A -56 ) GLY( 5 A -55 ) GLU( 5 A -54 ) ASP( 5 A -53 ) LEU( 5 A -52 ) LYS( 5 A -51 ) TRP( 5 A -50 ) GLU( 5 A -49 ) ALA( 5 A -48 ) SER( 5 A -47 ) ARG( 5 A -46 ) GLY( 5 A -45 ) GLY( 5 A -44 ) ALA( 5 A -43 ) ARG( 5 A -42 ) PHE( 5 A -41 ) PRO( 5 A -40 ) HIS( 5 A -39 ) LEU( 5 A -38 ) TYR( 5 A -37 ) ARG( 5 A -36 ) PRO( 5 A -35 ) LEU( 5 A -34 ) LEU( 5 A -33 ) VAL( 5 A -32 ) SER( 5 A -31 ) GLU( 5 A -30 ) VAL( 5 A -29 ) THR( 5 A -28 ) ARG( 5 A -27 ) GLU( 5 A -26 ) ALA( 5 A -25 ) ASP( 5 A -24 ) LEU( 5 A -23 ) ASP( 5 A -22 ) LEU( 5 A -21 ) ASP( 5 A -20 ) ALA( 5 A -19 ) ASP( 5 A -18 ) GLY( 5 A -17 ) VAL( 5 A -16 ) PRO( 5 A -15 ) GLN( 5 A -14 ) LEU( 5 A -13 ) GLY( 5 A -12 ) ASP( 5 A -11 ) HIS( 5 A -10 ) LEU( 5 A -9 ) ALA( 5 A -8 ) LEU( 5 A -7 ) GLU( 5 A -6 ) HIS( 5 A -5 ) HIS( 5 A -4 ) HIS( 5 A -3 ) HIS( 5 A -2 ) HIS( 5 A -1 ) HIS( 5 A 0 ) MET( 6 A-121 ) THR( 6 A-120 ) LEU( 6 A-119 ) ILE( 6 A-118 ) TYR( 6 A-117 ) LYS( 6 A-116 ) ILE( 6 A-115 ) LEU( 6 A-114 ) SER( 6 A-113 ) ARG( 6 A-112 ) ALA( 6 A-111 ) GLU( 6 A-110 ) TRP( 6 A-109 ) ASP( 6 A-108 ) ALA( 6 A-107 ) ALA( 6 A-106 ) LYS( 6 A-105 ) ALA( 6 A-104 ) GLN( 6 A-103 ) GLY( 6 A-102 ) ARG( 6 A-101 ) PHE( 6 A-100 ) GLU( 6 A -99 ) GLY( 6 A -98 ) SER( 6 A -97 ) ALA( 6 A -96 ) VAL( 6 A -95 ) ASP( 6 A -94 ) LEU( 6 A -93 ) ALA( 6 A -92 ) ASP( 6 A -91 ) GLY( 6 A -90 ) PHE( 6 A -89 ) ILE( 6 A -88 ) HIS( 6 A -87 ) LEU( 6 A -86 ) SER( 6 A -85 ) ALA( 6 A -84 ) GLY( 6 A -83 ) GLU( 6 A -82 ) GLN( 6 A -81 ) ALA( 6 A -80 ) GLN( 6 A -79 ) GLU( 6 A -78 ) THR( 6 A -77 ) ALA( 6 A -76 ) ALA( 6 A -75 ) LYS( 6 A -74 ) TRP( 6 A -73 ) PHE( 6 A -72 ) ARG( 6 A -71 ) GLY( 6 A -70 ) GLN( 6 A -69 ) ALA( 6 A -68 ) ASN( 6 A -67 ) LEU( 6 A -66 ) VAL( 6 A -65 ) LEU( 6 A -64 ) LEU( 6 A -63 ) ALA( 6 A -62 ) VAL( 6 A -61 ) GLU( 6 A -60 ) ALA( 6 A -59 ) GLU( 6 A -58 ) PRO( 6 A -57 ) LEU( 6 A -56 ) GLY( 6 A -55 ) GLU( 6 A -54 ) ASP( 6 A -53 ) LEU( 6 A -52 ) LYS( 6 A -51 ) TRP( 6 A -50 ) GLU( 6 A -49 ) ALA( 6 A -48 ) SER( 6 A -47 ) ARG( 6 A -46 ) GLY( 6 A -45 ) GLY( 6 A -44 ) ALA( 6 A -43 ) ARG( 6 A -42 ) PHE( 6 A -41 ) PRO( 6 A -40 ) HIS( 6 A -39 ) LEU( 6 A -38 ) TYR( 6 A -37 ) ARG( 6 A -36 ) PRO( 6 A -35 ) LEU( 6 A -34 ) LEU( 6 A -33 ) VAL( 6 A -32 ) SER( 6 A -31 ) GLU( 6 A -30 ) VAL( 6 A -29 ) THR( 6 A -28 ) ARG( 6 A -27 ) GLU( 6 A -26 ) ALA( 6 A -25 ) ASP( 6 A -24 ) LEU( 6 A -23 ) ASP( 6 A -22 ) LEU( 6 A -21 ) ASP( 6 A -20 ) ALA( 6 A -19 ) ASP( 6 A -18 ) GLY( 6 A -17 ) VAL( 6 A -16 ) PRO( 6 A -15 ) GLN( 6 A -14 ) LEU( 6 A -13 ) GLY( 6 A -12 ) ASP( 6 A -11 ) HIS( 6 A -10 ) LEU( 6 A -9 ) ALA( 6 A -8 ) LEU( 6 A -7 ) GLU( 6 A -6 ) HIS( 6 A -5 ) HIS( 6 A -4 ) HIS( 6 A -3 ) HIS( 6 A -2 ) HIS( 6 A -1 ) HIS( 6 A 0 ) MET( 7 A-121 ) THR( 7 A-120 ) LEU( 7 A-119 ) ILE( 7 A-118 ) TYR( 7 A-117 ) LYS( 7 A-116 ) ILE( 7 A-115 ) LEU( 7 A-114 ) SER( 7 A-113 ) ARG( 7 A-112 ) ALA( 7 A-111 ) GLU( 7 A-110 ) TRP( 7 A-109 ) ASP( 7 A-108 ) ALA( 7 A-107 ) ALA( 7 A-106 ) LYS( 7 A-105 ) ALA( 7 A-104 ) GLN( 7 A-103 ) GLY( 7 A-102 ) ARG( 7 A-101 ) PHE( 7 A-100 ) GLU( 7 A -99 ) GLY( 7 A -98 ) SER( 7 A -97 ) ALA( 7 A -96 ) VAL( 7 A -95 ) ASP( 7 A -94 ) LEU( 7 A -93 ) ALA( 7 A -92 ) ASP( 7 A -91 ) GLY( 7 A -90 ) PHE( 7 A -89 ) ILE( 7 A -88 ) HIS( 7 A -87 ) LEU( 7 A -86 ) SER( 7 A -85 ) ALA( 7 A -84 ) GLY( 7 A -83 ) GLU( 7 A -82 ) GLN( 7 A -81 ) ALA( 7 A -80 ) GLN( 7 A -79 ) GLU( 7 A -78 ) THR( 7 A -77 ) ALA( 7 A -76 ) ALA( 7 A -75 ) LYS( 7 A -74 ) TRP( 7 A -73 ) PHE( 7 A -72 ) ARG( 7 A -71 ) GLY( 7 A -70 ) GLN( 7 A -69 ) ALA( 7 A -68 ) ASN( 7 A -67 ) LEU( 7 A -66 ) VAL( 7 A -65 ) LEU( 7 A -64 ) LEU( 7 A -63 ) ALA( 7 A -62 ) VAL( 7 A -61 ) GLU( 7 A -60 ) ALA( 7 A -59 ) GLU( 7 A -58 ) PRO( 7 A -57 ) LEU( 7 A -56 ) GLY( 7 A -55 ) GLU( 7 A -54 ) ASP( 7 A -53 ) LEU( 7 A -52 ) LYS( 7 A -51 ) TRP( 7 A -50 ) GLU( 7 A -49 ) ALA( 7 A -48 ) SER( 7 A -47 ) ARG( 7 A -46 ) GLY( 7 A -45 ) GLY( 7 A -44 ) ALA( 7 A -43 ) ARG( 7 A -42 ) PHE( 7 A -41 ) PRO( 7 A -40 ) HIS( 7 A -39 ) LEU( 7 A -38 ) TYR( 7 A -37 ) ARG( 7 A -36 ) PRO( 7 A -35 ) LEU( 7 A -34 ) LEU( 7 A -33 ) VAL( 7 A -32 ) SER( 7 A -31 ) GLU( 7 A -30 ) VAL( 7 A -29 ) THR( 7 A -28 ) ARG( 7 A -27 ) GLU( 7 A -26 ) ALA( 7 A -25 ) ASP( 7 A -24 ) LEU( 7 A -23 ) ASP( 7 A -22 ) LEU( 7 A -21 ) ASP( 7 A -20 ) ALA( 7 A -19 ) ASP( 7 A -18 ) GLY( 7 A -17 ) VAL( 7 A -16 ) PRO( 7 A -15 ) GLN( 7 A -14 ) LEU( 7 A -13 ) GLY( 7 A -12 ) ASP( 7 A -11 ) HIS( 7 A -10 ) LEU( 7 A -9 ) ALA( 7 A -8 ) LEU( 7 A -7 ) GLU( 7 A -6 ) HIS( 7 A -5 ) HIS( 7 A -4 ) HIS( 7 A -3 ) HIS( 7 A -2 ) HIS( 7 A -1 ) HIS( 7 A 0 ) MET( 8 A-121 ) THR( 8 A-120 ) LEU( 8 A-119 ) ILE( 8 A-118 ) TYR( 8 A-117 ) LYS( 8 A-116 ) ILE( 8 A-115 ) LEU( 8 A-114 ) SER( 8 A-113 ) ARG( 8 A-112 ) ALA( 8 A-111 ) GLU( 8 A-110 ) TRP( 8 A-109 ) ASP( 8 A-108 ) ALA( 8 A-107 ) ALA( 8 A-106 ) LYS( 8 A-105 ) ALA( 8 A-104 ) GLN( 8 A-103 ) GLY( 8 A-102 ) ARG( 8 A-101 ) PHE( 8 A-100 ) GLU( 8 A -99 ) GLY( 8 A -98 ) SER( 8 A -97 ) ALA( 8 A -96 ) VAL( 8 A -95 ) ASP( 8 A -94 ) LEU( 8 A -93 ) ALA( 8 A -92 ) ASP( 8 A -91 ) GLY( 8 A -90 ) PHE( 8 A -89 ) ILE( 8 A -88 ) HIS( 8 A -87 ) LEU( 8 A -86 ) SER( 8 A -85 ) ALA( 8 A -84 ) GLY( 8 A -83 ) GLU( 8 A -82 ) GLN( 8 A -81 ) ALA( 8 A -80 ) GLN( 8 A -79 ) GLU( 8 A -78 ) THR( 8 A -77 ) ALA( 8 A -76 ) ALA( 8 A -75 ) LYS( 8 A -74 ) TRP( 8 A -73 ) PHE( 8 A -72 ) ARG( 8 A -71 ) GLY( 8 A -70 ) GLN( 8 A -69 ) ALA( 8 A -68 ) ASN( 8 A -67 ) LEU( 8 A -66 ) VAL( 8 A -65 ) LEU( 8 A -64 ) LEU( 8 A -63 ) ALA( 8 A -62 ) VAL( 8 A -61 ) GLU( 8 A -60 ) ALA( 8 A -59 ) GLU( 8 A -58 ) PRO( 8 A -57 ) LEU( 8 A -56 ) GLY( 8 A -55 ) GLU( 8 A -54 ) ASP( 8 A -53 ) LEU( 8 A -52 ) LYS( 8 A -51 ) TRP( 8 A -50 ) GLU( 8 A -49 ) ALA( 8 A -48 ) SER( 8 A -47 ) ARG( 8 A -46 ) GLY( 8 A -45 ) GLY( 8 A -44 ) ALA( 8 A -43 ) ARG( 8 A -42 ) PHE( 8 A -41 ) PRO( 8 A -40 ) HIS( 8 A -39 ) LEU( 8 A -38 ) TYR( 8 A -37 ) ARG( 8 A -36 ) PRO( 8 A -35 ) LEU( 8 A -34 ) LEU( 8 A -33 ) VAL( 8 A -32 ) SER( 8 A -31 ) GLU( 8 A -30 ) VAL( 8 A -29 ) THR( 8 A -28 ) ARG( 8 A -27 ) GLU( 8 A -26 ) ALA( 8 A -25 ) ASP( 8 A -24 ) LEU( 8 A -23 ) ASP( 8 A -22 ) LEU( 8 A -21 ) ASP( 8 A -20 ) ALA( 8 A -19 ) ASP( 8 A -18 ) GLY( 8 A -17 ) VAL( 8 A -16 ) PRO( 8 A -15 ) GLN( 8 A -14 ) LEU( 8 A -13 ) GLY( 8 A -12 ) ASP( 8 A -11 ) HIS( 8 A -10 ) LEU( 8 A -9 ) ALA( 8 A -8 ) LEU( 8 A -7 ) GLU( 8 A -6 ) HIS( 8 A -5 ) HIS( 8 A -4 ) HIS( 8 A -3 ) HIS( 8 A -2 ) HIS( 8 A -1 ) HIS( 8 A 0 ) MET( 9 A-121 ) THR( 9 A-120 ) LEU( 9 A-119 ) ILE( 9 A-118 ) TYR( 9 A-117 ) LYS( 9 A-116 ) ILE( 9 A-115 ) LEU( 9 A-114 ) SER( 9 A-113 ) ARG( 9 A-112 ) ALA( 9 A-111 ) GLU( 9 A-110 ) TRP( 9 A-109 ) ASP( 9 A-108 ) ALA( 9 A-107 ) ALA( 9 A-106 ) LYS( 9 A-105 ) ALA( 9 A-104 ) GLN( 9 A-103 ) GLY( 9 A-102 ) ARG( 9 A-101 ) PHE( 9 A-100 ) GLU( 9 A -99 ) GLY( 9 A -98 ) SER( 9 A -97 ) ALA( 9 A -96 ) VAL( 9 A -95 ) ASP( 9 A -94 ) LEU( 9 A -93 ) ALA( 9 A -92 ) ASP( 9 A -91 ) GLY( 9 A -90 ) PHE( 9 A -89 ) ILE( 9 A -88 ) HIS( 9 A -87 ) LEU( 9 A -86 ) SER( 9 A -85 ) ALA( 9 A -84 ) GLY( 9 A -83 ) GLU( 9 A -82 ) GLN( 9 A -81 ) ALA( 9 A -80 ) GLN( 9 A -79 ) GLU( 9 A -78 ) THR( 9 A -77 ) ALA( 9 A -76 ) ALA( 9 A -75 ) LYS( 9 A -74 ) TRP( 9 A -73 ) PHE( 9 A -72 ) ARG( 9 A -71 ) GLY( 9 A -70 ) GLN( 9 A -69 ) ALA( 9 A -68 ) ASN( 9 A -67 ) LEU( 9 A -66 ) VAL( 9 A -65 ) LEU( 9 A -64 ) LEU( 9 A -63 ) ALA( 9 A -62 ) VAL( 9 A -61 ) GLU( 9 A -60 ) ALA( 9 A -59 ) GLU( 9 A -58 ) PRO( 9 A -57 ) LEU( 9 A -56 ) GLY( 9 A -55 ) GLU( 9 A -54 ) ASP( 9 A -53 ) LEU( 9 A -52 ) LYS( 9 A -51 ) TRP( 9 A -50 ) GLU( 9 A -49 ) ALA( 9 A -48 ) SER( 9 A -47 ) ARG( 9 A -46 ) GLY( 9 A -45 ) GLY( 9 A -44 ) ALA( 9 A -43 ) ARG( 9 A -42 ) PHE( 9 A -41 ) PRO( 9 A -40 ) HIS( 9 A -39 ) LEU( 9 A -38 ) TYR( 9 A -37 ) ARG( 9 A -36 ) PRO( 9 A -35 ) LEU( 9 A -34 ) LEU( 9 A -33 ) VAL( 9 A -32 ) SER( 9 A -31 ) GLU( 9 A -30 ) VAL( 9 A -29 ) THR( 9 A -28 ) ARG( 9 A -27 ) GLU( 9 A -26 ) ALA( 9 A -25 ) ASP( 9 A -24 ) LEU( 9 A -23 ) ASP( 9 A -22 ) LEU( 9 A -21 ) ASP( 9 A -20 ) ALA( 9 A -19 ) ASP( 9 A -18 ) GLY( 9 A -17 ) VAL( 9 A -16 ) PRO( 9 A -15 ) GLN( 9 A -14 ) LEU( 9 A -13 ) GLY( 9 A -12 ) ASP( 9 A -11 ) HIS( 9 A -10 ) LEU( 9 A -9 ) ALA( 9 A -8 ) LEU( 9 A -7 ) GLU( 9 A -6 ) HIS( 9 A -5 ) HIS( 9 A -4 ) HIS( 9 A -3 ) HIS( 9 A -2 ) HIS( 9 A -1 ) HIS( 9 A 0 ) MET( 10 A-121 ) THR( 10 A-120 ) LEU( 10 A-119 ) ILE( 10 A-118 ) TYR( 10 A-117 ) LYS( 10 A-116 ) ILE( 10 A-115 ) LEU( 10 A-114 ) SER( 10 A-113 ) ARG( 10 A-112 ) ALA( 10 A-111 ) GLU( 10 A-110 ) TRP( 10 A-109 ) ASP( 10 A-108 ) ALA( 10 A-107 ) ALA( 10 A-106 ) LYS( 10 A-105 ) ALA( 10 A-104 ) GLN( 10 A-103 ) GLY( 10 A-102 ) ARG( 10 A-101 ) PHE( 10 A-100 ) GLU( 10 A -99 ) GLY( 10 A -98 ) SER( 10 A -97 ) ALA( 10 A -96 ) VAL( 10 A -95 ) ASP( 10 A -94 ) LEU( 10 A -93 ) ALA( 10 A -92 ) ASP( 10 A -91 ) GLY( 10 A -90 ) PHE( 10 A -89 ) ILE( 10 A -88 ) HIS( 10 A -87 ) LEU( 10 A -86 ) SER( 10 A -85 ) ALA( 10 A -84 ) GLY( 10 A -83 ) GLU( 10 A -82 ) GLN( 10 A -81 ) ALA( 10 A -80 ) GLN( 10 A -79 ) GLU( 10 A -78 ) THR( 10 A -77 ) ALA( 10 A -76 ) ALA( 10 A -75 ) LYS( 10 A -74 ) TRP( 10 A -73 ) PHE( 10 A -72 ) ARG( 10 A -71 ) GLY( 10 A -70 ) GLN( 10 A -69 ) ALA( 10 A -68 ) ASN( 10 A -67 ) LEU( 10 A -66 ) VAL( 10 A -65 ) LEU( 10 A -64 ) LEU( 10 A -63 ) ALA( 10 A -62 ) VAL( 10 A -61 ) GLU( 10 A -60 ) ALA( 10 A -59 ) GLU( 10 A -58 ) PRO( 10 A -57 ) LEU( 10 A -56 ) GLY( 10 A -55 ) GLU( 10 A -54 ) ASP( 10 A -53 ) LEU( 10 A -52 ) LYS( 10 A -51 ) TRP( 10 A -50 ) GLU( 10 A -49 ) ALA( 10 A -48 ) SER( 10 A -47 ) ARG( 10 A -46 ) GLY( 10 A -45 ) GLY( 10 A -44 ) ALA( 10 A -43 ) ARG( 10 A -42 ) PHE( 10 A -41 ) PRO( 10 A -40 ) HIS( 10 A -39 ) LEU( 10 A -38 ) TYR( 10 A -37 ) ARG( 10 A -36 ) PRO( 10 A -35 ) LEU( 10 A -34 ) LEU( 10 A -33 ) VAL( 10 A -32 ) SER( 10 A -31 ) GLU( 10 A -30 ) VAL( 10 A -29 ) THR( 10 A -28 ) ARG( 10 A -27 ) GLU( 10 A -26 ) ALA( 10 A -25 ) ASP( 10 A -24 ) LEU( 10 A -23 ) ASP( 10 A -22 ) LEU( 10 A -21 ) ASP( 10 A -20 ) ALA( 10 A -19 ) ASP( 10 A -18 ) GLY( 10 A -17 ) VAL( 10 A -16 ) PRO( 10 A -15 ) GLN( 10 A -14 ) LEU( 10 A -13 ) GLY( 10 A -12 ) ASP( 10 A -11 ) HIS( 10 A -10 ) LEU( 10 A -9 ) ALA( 10 A -8 ) LEU( 10 A -7 ) GLU( 10 A -6 ) HIS( 10 A -5 ) HIS( 10 A -4 ) HIS( 10 A -3 ) HIS( 10 A -2 ) HIS( 10 A -1 ) HIS( 10 A 0 ) MET( 11 A-121 ) THR( 11 A-120 ) LEU( 11 A-119 ) ILE( 11 A-118 ) TYR( 11 A-117 ) LYS( 11 A-116 ) ILE( 11 A-115 ) LEU( 11 A-114 ) SER( 11 A-113 ) ARG( 11 A-112 ) ALA( 11 A-111 ) GLU( 11 A-110 ) TRP( 11 A-109 ) ASP( 11 A-108 ) ALA( 11 A-107 ) ALA( 11 A-106 ) LYS( 11 A-105 ) ALA( 11 A-104 ) GLN( 11 A-103 ) GLY( 11 A-102 ) ARG( 11 A-101 ) PHE( 11 A-100 ) GLU( 11 A -99 ) GLY( 11 A -98 ) SER( 11 A -97 ) ALA( 11 A -96 ) VAL( 11 A -95 ) ASP( 11 A -94 ) LEU( 11 A -93 ) ALA( 11 A -92 ) ASP( 11 A -91 ) GLY( 11 A -90 ) PHE( 11 A -89 ) ILE( 11 A -88 ) HIS( 11 A -87 ) LEU( 11 A -86 ) SER( 11 A -85 ) ALA( 11 A -84 ) GLY( 11 A -83 ) GLU( 11 A -82 ) GLN( 11 A -81 ) ALA( 11 A -80 ) GLN( 11 A -79 ) GLU( 11 A -78 ) THR( 11 A -77 ) ALA( 11 A -76 ) ALA( 11 A -75 ) LYS( 11 A -74 ) TRP( 11 A -73 ) PHE( 11 A -72 ) ARG( 11 A -71 ) GLY( 11 A -70 ) GLN( 11 A -69 ) ALA( 11 A -68 ) ASN( 11 A -67 ) LEU( 11 A -66 ) VAL( 11 A -65 ) LEU( 11 A -64 ) LEU( 11 A -63 ) ALA( 11 A -62 ) VAL( 11 A -61 ) GLU( 11 A -60 ) ALA( 11 A -59 ) GLU( 11 A -58 ) PRO( 11 A -57 ) LEU( 11 A -56 ) GLY( 11 A -55 ) GLU( 11 A -54 ) ASP( 11 A -53 ) LEU( 11 A -52 ) LYS( 11 A -51 ) TRP( 11 A -50 ) GLU( 11 A -49 ) ALA( 11 A -48 ) SER( 11 A -47 ) ARG( 11 A -46 ) GLY( 11 A -45 ) GLY( 11 A -44 ) ALA( 11 A -43 ) ARG( 11 A -42 ) PHE( 11 A -41 ) PRO( 11 A -40 ) HIS( 11 A -39 ) LEU( 11 A -38 ) TYR( 11 A -37 ) ARG( 11 A -36 ) PRO( 11 A -35 ) LEU( 11 A -34 ) LEU( 11 A -33 ) VAL( 11 A -32 ) SER( 11 A -31 ) GLU( 11 A -30 ) VAL( 11 A -29 ) THR( 11 A -28 ) ARG( 11 A -27 ) GLU( 11 A -26 ) ALA( 11 A -25 ) ASP( 11 A -24 ) LEU( 11 A -23 ) ASP( 11 A -22 ) LEU( 11 A -21 ) ASP( 11 A -20 ) ALA( 11 A -19 ) ASP( 11 A -18 ) GLY( 11 A -17 ) VAL( 11 A -16 ) PRO( 11 A -15 ) GLN( 11 A -14 ) LEU( 11 A -13 ) GLY( 11 A -12 ) ASP( 11 A -11 ) HIS( 11 A -10 ) LEU( 11 A -9 ) ALA( 11 A -8 ) LEU( 11 A -7 ) GLU( 11 A -6 ) HIS( 11 A -5 ) HIS( 11 A -4 ) HIS( 11 A -3 ) HIS( 11 A -2 ) HIS( 11 A -1 ) HIS( 11 A 0 ) MET( 12 A-121 ) THR( 12 A-120 ) LEU( 12 A-119 ) ILE( 12 A-118 ) TYR( 12 A-117 ) LYS( 12 A-116 ) ILE( 12 A-115 ) LEU( 12 A-114 ) SER( 12 A-113 ) ARG( 12 A-112 ) ALA( 12 A-111 ) GLU( 12 A-110 ) TRP( 12 A-109 ) ASP( 12 A-108 ) ALA( 12 A-107 ) ALA( 12 A-106 ) LYS( 12 A-105 ) ALA( 12 A-104 ) GLN( 12 A-103 ) GLY( 12 A-102 ) ARG( 12 A-101 ) PHE( 12 A-100 ) GLU( 12 A -99 ) GLY( 12 A -98 ) SER( 12 A -97 ) ALA( 12 A -96 ) VAL( 12 A -95 ) ASP( 12 A -94 ) LEU( 12 A -93 ) ALA( 12 A -92 ) ASP( 12 A -91 ) GLY( 12 A -90 ) PHE( 12 A -89 ) ILE( 12 A -88 ) HIS( 12 A -87 ) LEU( 12 A -86 ) SER( 12 A -85 ) ALA( 12 A -84 ) GLY( 12 A -83 ) GLU( 12 A -82 ) GLN( 12 A -81 ) ALA( 12 A -80 ) GLN( 12 A -79 ) GLU( 12 A -78 ) THR( 12 A -77 ) ALA( 12 A -76 ) ALA( 12 A -75 ) LYS( 12 A -74 ) TRP( 12 A -73 ) PHE( 12 A -72 ) ARG( 12 A -71 ) GLY( 12 A -70 ) GLN( 12 A -69 ) ALA( 12 A -68 ) ASN( 12 A -67 ) LEU( 12 A -66 ) VAL( 12 A -65 ) LEU( 12 A -64 ) LEU( 12 A -63 ) ALA( 12 A -62 ) VAL( 12 A -61 ) GLU( 12 A -60 ) ALA( 12 A -59 ) GLU( 12 A -58 ) PRO( 12 A -57 ) LEU( 12 A -56 ) GLY( 12 A -55 ) GLU( 12 A -54 ) ASP( 12 A -53 ) LEU( 12 A -52 ) LYS( 12 A -51 ) TRP( 12 A -50 ) GLU( 12 A -49 ) ALA( 12 A -48 ) SER( 12 A -47 ) ARG( 12 A -46 ) GLY( 12 A -45 ) GLY( 12 A -44 ) ALA( 12 A -43 ) ARG( 12 A -42 ) PHE( 12 A -41 ) PRO( 12 A -40 ) HIS( 12 A -39 ) LEU( 12 A -38 ) TYR( 12 A -37 ) ARG( 12 A -36 ) PRO( 12 A -35 ) LEU( 12 A -34 ) LEU( 12 A -33 ) VAL( 12 A -32 ) SER( 12 A -31 ) GLU( 12 A -30 ) VAL( 12 A -29 ) THR( 12 A -28 ) ARG( 12 A -27 ) GLU( 12 A -26 ) ALA( 12 A -25 ) ASP( 12 A -24 ) LEU( 12 A -23 ) ASP( 12 A -22 ) LEU( 12 A -21 ) ASP( 12 A -20 ) ALA( 12 A -19 ) ASP( 12 A -18 ) GLY( 12 A -17 ) VAL( 12 A -16 ) PRO( 12 A -15 ) GLN( 12 A -14 ) LEU( 12 A -13 ) GLY( 12 A -12 ) ASP( 12 A -11 ) HIS( 12 A -10 ) LEU( 12 A -9 ) ALA( 12 A -8 ) LEU( 12 A -7 ) GLU( 12 A -6 ) HIS( 12 A -5 ) HIS( 12 A -4 ) HIS( 12 A -3 ) HIS( 12 A -2 ) HIS( 12 A -1 ) HIS( 12 A 0 ) MET( 13 A-121 ) THR( 13 A-120 ) LEU( 13 A-119 ) ILE( 13 A-118 ) TYR( 13 A-117 ) LYS( 13 A-116 ) ILE( 13 A-115 ) LEU( 13 A-114 ) SER( 13 A-113 ) ARG( 13 A-112 ) ALA( 13 A-111 ) GLU( 13 A-110 ) TRP( 13 A-109 ) ASP( 13 A-108 ) ALA( 13 A-107 ) ALA( 13 A-106 ) LYS( 13 A-105 ) ALA( 13 A-104 ) GLN( 13 A-103 ) GLY( 13 A-102 ) ARG( 13 A-101 ) PHE( 13 A-100 ) GLU( 13 A -99 ) GLY( 13 A -98 ) SER( 13 A -97 ) ALA( 13 A -96 ) VAL( 13 A -95 ) ASP( 13 A -94 ) LEU( 13 A -93 ) ALA( 13 A -92 ) ASP( 13 A -91 ) GLY( 13 A -90 ) PHE( 13 A -89 ) ILE( 13 A -88 ) HIS( 13 A -87 ) LEU( 13 A -86 ) SER( 13 A -85 ) ALA( 13 A -84 ) GLY( 13 A -83 ) GLU( 13 A -82 ) GLN( 13 A -81 ) ALA( 13 A -80 ) GLN( 13 A -79 ) GLU( 13 A -78 ) THR( 13 A -77 ) ALA( 13 A -76 ) ALA( 13 A -75 ) LYS( 13 A -74 ) TRP( 13 A -73 ) PHE( 13 A -72 ) ARG( 13 A -71 ) GLY( 13 A -70 ) GLN( 13 A -69 ) ALA( 13 A -68 ) ASN( 13 A -67 ) LEU( 13 A -66 ) VAL( 13 A -65 ) LEU( 13 A -64 ) LEU( 13 A -63 ) ALA( 13 A -62 ) VAL( 13 A -61 ) GLU( 13 A -60 ) ALA( 13 A -59 ) GLU( 13 A -58 ) PRO( 13 A -57 ) LEU( 13 A -56 ) GLY( 13 A -55 ) GLU( 13 A -54 ) ASP( 13 A -53 ) LEU( 13 A -52 ) LYS( 13 A -51 ) TRP( 13 A -50 ) GLU( 13 A -49 ) ALA( 13 A -48 ) SER( 13 A -47 ) ARG( 13 A -46 ) GLY( 13 A -45 ) GLY( 13 A -44 ) ALA( 13 A -43 ) ARG( 13 A -42 ) PHE( 13 A -41 ) PRO( 13 A -40 ) HIS( 13 A -39 ) LEU( 13 A -38 ) TYR( 13 A -37 ) ARG( 13 A -36 ) PRO( 13 A -35 ) LEU( 13 A -34 ) LEU( 13 A -33 ) VAL( 13 A -32 ) SER( 13 A -31 ) GLU( 13 A -30 ) VAL( 13 A -29 ) THR( 13 A -28 ) ARG( 13 A -27 ) GLU( 13 A -26 ) ALA( 13 A -25 ) ASP( 13 A -24 ) LEU( 13 A -23 ) ASP( 13 A -22 ) LEU( 13 A -21 ) ASP( 13 A -20 ) ALA( 13 A -19 ) ASP( 13 A -18 ) GLY( 13 A -17 ) VAL( 13 A -16 ) PRO( 13 A -15 ) GLN( 13 A -14 ) LEU( 13 A -13 ) GLY( 13 A -12 ) ASP( 13 A -11 ) HIS( 13 A -10 ) LEU( 13 A -9 ) ALA( 13 A -8 ) LEU( 13 A -7 ) GLU( 13 A -6 ) HIS( 13 A -5 ) HIS( 13 A -4 ) HIS( 13 A -3 ) HIS( 13 A -2 ) HIS( 13 A -1 ) HIS( 13 A 0 ) MET( 14 A-121 ) THR( 14 A-120 ) LEU( 14 A-119 ) ILE( 14 A-118 ) TYR( 14 A-117 ) LYS( 14 A-116 ) ILE( 14 A-115 ) LEU( 14 A-114 ) SER( 14 A-113 ) ARG( 14 A-112 ) ALA( 14 A-111 ) GLU( 14 A-110 ) TRP( 14 A-109 ) ASP( 14 A-108 ) ALA( 14 A-107 ) ALA( 14 A-106 ) LYS( 14 A-105 ) ALA( 14 A-104 ) GLN( 14 A-103 ) GLY( 14 A-102 ) ARG( 14 A-101 ) PHE( 14 A-100 ) GLU( 14 A -99 ) GLY( 14 A -98 ) SER( 14 A -97 ) ALA( 14 A -96 ) VAL( 14 A -95 ) ASP( 14 A -94 ) LEU( 14 A -93 ) ALA( 14 A -92 ) ASP( 14 A -91 ) GLY( 14 A -90 ) PHE( 14 A -89 ) ILE( 14 A -88 ) HIS( 14 A -87 ) LEU( 14 A -86 ) SER( 14 A -85 ) ALA( 14 A -84 ) GLY( 14 A -83 ) GLU( 14 A -82 ) GLN( 14 A -81 ) ALA( 14 A -80 ) GLN( 14 A -79 ) GLU( 14 A -78 ) THR( 14 A -77 ) ALA( 14 A -76 ) ALA( 14 A -75 ) LYS( 14 A -74 ) TRP( 14 A -73 ) PHE( 14 A -72 ) ARG( 14 A -71 ) GLY( 14 A -70 ) GLN( 14 A -69 ) ALA( 14 A -68 ) ASN( 14 A -67 ) LEU( 14 A -66 ) VAL( 14 A -65 ) LEU( 14 A -64 ) LEU( 14 A -63 ) ALA( 14 A -62 ) VAL( 14 A -61 ) GLU( 14 A -60 ) ALA( 14 A -59 ) GLU( 14 A -58 ) PRO( 14 A -57 ) LEU( 14 A -56 ) GLY( 14 A -55 ) GLU( 14 A -54 ) ASP( 14 A -53 ) LEU( 14 A -52 ) LYS( 14 A -51 ) TRP( 14 A -50 ) GLU( 14 A -49 ) ALA( 14 A -48 ) SER( 14 A -47 ) ARG( 14 A -46 ) GLY( 14 A -45 ) GLY( 14 A -44 ) ALA( 14 A -43 ) ARG( 14 A -42 ) PHE( 14 A -41 ) PRO( 14 A -40 ) HIS( 14 A -39 ) LEU( 14 A -38 ) TYR( 14 A -37 ) ARG( 14 A -36 ) PRO( 14 A -35 ) LEU( 14 A -34 ) LEU( 14 A -33 ) VAL( 14 A -32 ) SER( 14 A -31 ) GLU( 14 A -30 ) VAL( 14 A -29 ) THR( 14 A -28 ) ARG( 14 A -27 ) GLU( 14 A -26 ) ALA( 14 A -25 ) ASP( 14 A -24 ) LEU( 14 A -23 ) ASP( 14 A -22 ) LEU( 14 A -21 ) ASP( 14 A -20 ) ALA( 14 A -19 ) ASP( 14 A -18 ) GLY( 14 A -17 ) VAL( 14 A -16 ) PRO( 14 A -15 ) GLN( 14 A -14 ) LEU( 14 A -13 ) GLY( 14 A -12 ) ASP( 14 A -11 ) HIS( 14 A -10 ) LEU( 14 A -9 ) ALA( 14 A -8 ) LEU( 14 A -7 ) GLU( 14 A -6 ) HIS( 14 A -5 ) HIS( 14 A -4 ) HIS( 14 A -3 ) HIS( 14 A -2 ) HIS( 14 A -1 ) HIS( 14 A 0 ) MET( 15 A-121 ) THR( 15 A-120 ) LEU( 15 A-119 ) ILE( 15 A-118 ) TYR( 15 A-117 ) LYS( 15 A-116 ) ILE( 15 A-115 ) LEU( 15 A-114 ) SER( 15 A-113 ) ARG( 15 A-112 ) ALA( 15 A-111 ) GLU( 15 A-110 ) TRP( 15 A-109 ) ASP( 15 A-108 ) ALA( 15 A-107 ) ALA( 15 A-106 ) LYS( 15 A-105 ) ALA( 15 A-104 ) GLN( 15 A-103 ) GLY( 15 A-102 ) ARG( 15 A-101 ) PHE( 15 A-100 ) GLU( 15 A -99 ) GLY( 15 A -98 ) SER( 15 A -97 ) ALA( 15 A -96 ) VAL( 15 A -95 ) ASP( 15 A -94 ) LEU( 15 A -93 ) ALA( 15 A -92 ) ASP( 15 A -91 ) GLY( 15 A -90 ) PHE( 15 A -89 ) ILE( 15 A -88 ) HIS( 15 A -87 ) LEU( 15 A -86 ) SER( 15 A -85 ) ALA( 15 A -84 ) GLY( 15 A -83 ) GLU( 15 A -82 ) GLN( 15 A -81 ) ALA( 15 A -80 ) GLN( 15 A -79 ) GLU( 15 A -78 ) THR( 15 A -77 ) ALA( 15 A -76 ) ALA( 15 A -75 ) LYS( 15 A -74 ) TRP( 15 A -73 ) PHE( 15 A -72 ) ARG( 15 A -71 ) GLY( 15 A -70 ) GLN( 15 A -69 ) ALA( 15 A -68 ) ASN( 15 A -67 ) LEU( 15 A -66 ) VAL( 15 A -65 ) LEU( 15 A -64 ) LEU( 15 A -63 ) ALA( 15 A -62 ) VAL( 15 A -61 ) GLU( 15 A -60 ) ALA( 15 A -59 ) GLU( 15 A -58 ) PRO( 15 A -57 ) LEU( 15 A -56 ) GLY( 15 A -55 ) GLU( 15 A -54 ) ASP( 15 A -53 ) LEU( 15 A -52 ) LYS( 15 A -51 ) TRP( 15 A -50 ) GLU( 15 A -49 ) ALA( 15 A -48 ) SER( 15 A -47 ) ARG( 15 A -46 ) GLY( 15 A -45 ) GLY( 15 A -44 ) ALA( 15 A -43 ) ARG( 15 A -42 ) PHE( 15 A -41 ) PRO( 15 A -40 ) HIS( 15 A -39 ) LEU( 15 A -38 ) TYR( 15 A -37 ) ARG( 15 A -36 ) PRO( 15 A -35 ) LEU( 15 A -34 ) LEU( 15 A -33 ) VAL( 15 A -32 ) SER( 15 A -31 ) GLU( 15 A -30 ) VAL( 15 A -29 ) THR( 15 A -28 ) ARG( 15 A -27 ) GLU( 15 A -26 ) ALA( 15 A -25 ) ASP( 15 A -24 ) LEU( 15 A -23 ) ASP( 15 A -22 ) LEU( 15 A -21 ) ASP( 15 A -20 ) ALA( 15 A -19 ) ASP( 15 A -18 ) GLY( 15 A -17 ) VAL( 15 A -16 ) PRO( 15 A -15 ) GLN( 15 A -14 ) LEU( 15 A -13 ) GLY( 15 A -12 ) ASP( 15 A -11 ) HIS( 15 A -10 ) LEU( 15 A -9 ) ALA( 15 A -8 ) LEU( 15 A -7 ) GLU( 15 A -6 ) HIS( 15 A -5 ) HIS( 15 A -4 ) HIS( 15 A -3 ) HIS( 15 A -2 ) HIS( 15 A -1 ) HIS( 15 A 0 ) MET( 16 A-121 ) THR( 16 A-120 ) LEU( 16 A-119 ) ILE( 16 A-118 ) TYR( 16 A-117 ) LYS( 16 A-116 ) ILE( 16 A-115 ) LEU( 16 A-114 ) SER( 16 A-113 ) ARG( 16 A-112 ) ALA( 16 A-111 ) GLU( 16 A-110 ) TRP( 16 A-109 ) ASP( 16 A-108 ) ALA( 16 A-107 ) ALA( 16 A-106 ) LYS( 16 A-105 ) ALA( 16 A-104 ) GLN( 16 A-103 ) GLY( 16 A-102 ) ARG( 16 A-101 ) PHE( 16 A-100 ) GLU( 16 A -99 ) GLY( 16 A -98 ) SER( 16 A -97 ) ALA( 16 A -96 ) VAL( 16 A -95 ) ASP( 16 A -94 ) LEU( 16 A -93 ) ALA( 16 A -92 ) ASP( 16 A -91 ) GLY( 16 A -90 ) PHE( 16 A -89 ) ILE( 16 A -88 ) HIS( 16 A -87 ) LEU( 16 A -86 ) SER( 16 A -85 ) ALA( 16 A -84 ) GLY( 16 A -83 ) GLU( 16 A -82 ) GLN( 16 A -81 ) ALA( 16 A -80 ) GLN( 16 A -79 ) GLU( 16 A -78 ) THR( 16 A -77 ) ALA( 16 A -76 ) ALA( 16 A -75 ) LYS( 16 A -74 ) TRP( 16 A -73 ) PHE( 16 A -72 ) ARG( 16 A -71 ) GLY( 16 A -70 ) GLN( 16 A -69 ) ALA( 16 A -68 ) ASN( 16 A -67 ) LEU( 16 A -66 ) VAL( 16 A -65 ) LEU( 16 A -64 ) LEU( 16 A -63 ) ALA( 16 A -62 ) VAL( 16 A -61 ) GLU( 16 A -60 ) ALA( 16 A -59 ) GLU( 16 A -58 ) PRO( 16 A -57 ) LEU( 16 A -56 ) GLY( 16 A -55 ) GLU( 16 A -54 ) ASP( 16 A -53 ) LEU( 16 A -52 ) LYS( 16 A -51 ) TRP( 16 A -50 ) GLU( 16 A -49 ) ALA( 16 A -48 ) SER( 16 A -47 ) ARG( 16 A -46 ) GLY( 16 A -45 ) GLY( 16 A -44 ) ALA( 16 A -43 ) ARG( 16 A -42 ) PHE( 16 A -41 ) PRO( 16 A -40 ) HIS( 16 A -39 ) LEU( 16 A -38 ) TYR( 16 A -37 ) ARG( 16 A -36 ) PRO( 16 A -35 ) LEU( 16 A -34 ) LEU( 16 A -33 ) VAL( 16 A -32 ) SER( 16 A -31 ) GLU( 16 A -30 ) VAL( 16 A -29 ) THR( 16 A -28 ) ARG( 16 A -27 ) GLU( 16 A -26 ) ALA( 16 A -25 ) ASP( 16 A -24 ) LEU( 16 A -23 ) ASP( 16 A -22 ) LEU( 16 A -21 ) ASP( 16 A -20 ) ALA( 16 A -19 ) ASP( 16 A -18 ) GLY( 16 A -17 ) VAL( 16 A -16 ) PRO( 16 A -15 ) GLN( 16 A -14 ) LEU( 16 A -13 ) GLY( 16 A -12 ) ASP( 16 A -11 ) HIS( 16 A -10 ) LEU( 16 A -9 ) ALA( 16 A -8 ) LEU( 16 A -7 ) GLU( 16 A -6 ) HIS( 16 A -5 ) HIS( 16 A -4 ) HIS( 16 A -3 ) HIS( 16 A -2 ) HIS( 16 A -1 ) HIS( 16 A 0 ) MET( 17 A-121 ) THR( 17 A-120 ) LEU( 17 A-119 ) ILE( 17 A-118 ) TYR( 17 A-117 ) LYS( 17 A-116 ) ILE( 17 A-115 ) LEU( 17 A-114 ) SER( 17 A-113 ) ARG( 17 A-112 ) ALA( 17 A-111 ) GLU( 17 A-110 ) TRP( 17 A-109 ) ASP( 17 A-108 ) ALA( 17 A-107 ) ALA( 17 A-106 ) LYS( 17 A-105 ) ALA( 17 A-104 ) GLN( 17 A-103 ) GLY( 17 A-102 ) ARG( 17 A-101 ) PHE( 17 A-100 ) GLU( 17 A -99 ) GLY( 17 A -98 ) SER( 17 A -97 ) ALA( 17 A -96 ) VAL( 17 A -95 ) ASP( 17 A -94 ) LEU( 17 A -93 ) ALA( 17 A -92 ) ASP( 17 A -91 ) GLY( 17 A -90 ) PHE( 17 A -89 ) ILE( 17 A -88 ) HIS( 17 A -87 ) LEU( 17 A -86 ) SER( 17 A -85 ) ALA( 17 A -84 ) GLY( 17 A -83 ) GLU( 17 A -82 ) GLN( 17 A -81 ) ALA( 17 A -80 ) GLN( 17 A -79 ) GLU( 17 A -78 ) THR( 17 A -77 ) ALA( 17 A -76 ) ALA( 17 A -75 ) LYS( 17 A -74 ) TRP( 17 A -73 ) PHE( 17 A -72 ) ARG( 17 A -71 ) GLY( 17 A -70 ) GLN( 17 A -69 ) ALA( 17 A -68 ) ASN( 17 A -67 ) LEU( 17 A -66 ) VAL( 17 A -65 ) LEU( 17 A -64 ) LEU( 17 A -63 ) ALA( 17 A -62 ) VAL( 17 A -61 ) GLU( 17 A -60 ) ALA( 17 A -59 ) GLU( 17 A -58 ) PRO( 17 A -57 ) LEU( 17 A -56 ) GLY( 17 A -55 ) GLU( 17 A -54 ) ASP( 17 A -53 ) LEU( 17 A -52 ) LYS( 17 A -51 ) TRP( 17 A -50 ) GLU( 17 A -49 ) ALA( 17 A -48 ) SER( 17 A -47 ) ARG( 17 A -46 ) GLY( 17 A -45 ) GLY( 17 A -44 ) ALA( 17 A -43 ) ARG( 17 A -42 ) PHE( 17 A -41 ) PRO( 17 A -40 ) HIS( 17 A -39 ) LEU( 17 A -38 ) TYR( 17 A -37 ) ARG( 17 A -36 ) PRO( 17 A -35 ) LEU( 17 A -34 ) LEU( 17 A -33 ) VAL( 17 A -32 ) SER( 17 A -31 ) GLU( 17 A -30 ) VAL( 17 A -29 ) THR( 17 A -28 ) ARG( 17 A -27 ) GLU( 17 A -26 ) ALA( 17 A -25 ) ASP( 17 A -24 ) LEU( 17 A -23 ) ASP( 17 A -22 ) LEU( 17 A -21 ) ASP( 17 A -20 ) ALA( 17 A -19 ) ASP( 17 A -18 ) GLY( 17 A -17 ) VAL( 17 A -16 ) PRO( 17 A -15 ) GLN( 17 A -14 ) LEU( 17 A -13 ) GLY( 17 A -12 ) ASP( 17 A -11 ) HIS( 17 A -10 ) LEU( 17 A -9 ) ALA( 17 A -8 ) LEU( 17 A -7 ) GLU( 17 A -6 ) HIS( 17 A -5 ) HIS( 17 A -4 ) HIS( 17 A -3 ) HIS( 17 A -2 ) HIS( 17 A -1 ) HIS( 17 A 0 ) MET( 18 A-121 ) THR( 18 A-120 ) LEU( 18 A-119 ) ILE( 18 A-118 ) TYR( 18 A-117 ) LYS( 18 A-116 ) ILE( 18 A-115 ) LEU( 18 A-114 ) SER( 18 A-113 ) ARG( 18 A-112 ) ALA( 18 A-111 ) GLU( 18 A-110 ) TRP( 18 A-109 ) ASP( 18 A-108 ) ALA( 18 A-107 ) ALA( 18 A-106 ) LYS( 18 A-105 ) ALA( 18 A-104 ) GLN( 18 A-103 ) GLY( 18 A-102 ) ARG( 18 A-101 ) PHE( 18 A-100 ) GLU( 18 A -99 ) GLY( 18 A -98 ) SER( 18 A -97 ) ALA( 18 A -96 ) VAL( 18 A -95 ) ASP( 18 A -94 ) LEU( 18 A -93 ) ALA( 18 A -92 ) ASP( 18 A -91 ) GLY( 18 A -90 ) PHE( 18 A -89 ) ILE( 18 A -88 ) HIS( 18 A -87 ) LEU( 18 A -86 ) SER( 18 A -85 ) ALA( 18 A -84 ) GLY( 18 A -83 ) GLU( 18 A -82 ) GLN( 18 A -81 ) ALA( 18 A -80 ) GLN( 18 A -79 ) GLU( 18 A -78 ) THR( 18 A -77 ) ALA( 18 A -76 ) ALA( 18 A -75 ) LYS( 18 A -74 ) TRP( 18 A -73 ) PHE( 18 A -72 ) ARG( 18 A -71 ) GLY( 18 A -70 ) GLN( 18 A -69 ) ALA( 18 A -68 ) ASN( 18 A -67 ) LEU( 18 A -66 ) VAL( 18 A -65 ) LEU( 18 A -64 ) LEU( 18 A -63 ) ALA( 18 A -62 ) VAL( 18 A -61 ) GLU( 18 A -60 ) ALA( 18 A -59 ) GLU( 18 A -58 ) PRO( 18 A -57 ) LEU( 18 A -56 ) GLY( 18 A -55 ) GLU( 18 A -54 ) ASP( 18 A -53 ) LEU( 18 A -52 ) LYS( 18 A -51 ) TRP( 18 A -50 ) GLU( 18 A -49 ) ALA( 18 A -48 ) SER( 18 A -47 ) ARG( 18 A -46 ) GLY( 18 A -45 ) GLY( 18 A -44 ) ALA( 18 A -43 ) ARG( 18 A -42 ) PHE( 18 A -41 ) PRO( 18 A -40 ) HIS( 18 A -39 ) LEU( 18 A -38 ) TYR( 18 A -37 ) ARG( 18 A -36 ) PRO( 18 A -35 ) LEU( 18 A -34 ) LEU( 18 A -33 ) VAL( 18 A -32 ) SER( 18 A -31 ) GLU( 18 A -30 ) VAL( 18 A -29 ) THR( 18 A -28 ) ARG( 18 A -27 ) GLU( 18 A -26 ) ALA( 18 A -25 ) ASP( 18 A -24 ) LEU( 18 A -23 ) ASP( 18 A -22 ) LEU( 18 A -21 ) ASP( 18 A -20 ) ALA( 18 A -19 ) ASP( 18 A -18 ) GLY( 18 A -17 ) VAL( 18 A -16 ) PRO( 18 A -15 ) GLN( 18 A -14 ) LEU( 18 A -13 ) GLY( 18 A -12 ) ASP( 18 A -11 ) HIS( 18 A -10 ) LEU( 18 A -9 ) ALA( 18 A -8 ) LEU( 18 A -7 ) GLU( 18 A -6 ) HIS( 18 A -5 ) HIS( 18 A -4 ) HIS( 18 A -3 ) HIS( 18 A -2 ) HIS( 18 A -1 ) HIS( 18 A 0 ) MET( 19 A-121 ) THR( 19 A-120 ) LEU( 19 A-119 ) ILE( 19 A-118 ) TYR( 19 A-117 ) LYS( 19 A-116 ) ILE( 19 A-115 ) LEU( 19 A-114 ) SER( 19 A-113 ) ARG( 19 A-112 ) ALA( 19 A-111 ) GLU( 19 A-110 ) TRP( 19 A-109 ) ASP( 19 A-108 ) ALA( 19 A-107 ) ALA( 19 A-106 ) LYS( 19 A-105 ) ALA( 19 A-104 ) GLN( 19 A-103 ) GLY( 19 A-102 ) ARG( 19 A-101 ) PHE( 19 A-100 ) GLU( 19 A -99 ) GLY( 19 A -98 ) SER( 19 A -97 ) ALA( 19 A -96 ) VAL( 19 A -95 ) ASP( 19 A -94 ) LEU( 19 A -93 ) ALA( 19 A -92 ) ASP( 19 A -91 ) GLY( 19 A -90 ) PHE( 19 A -89 ) ILE( 19 A -88 ) HIS( 19 A -87 ) LEU( 19 A -86 ) SER( 19 A -85 ) ALA( 19 A -84 ) GLY( 19 A -83 ) GLU( 19 A -82 ) GLN( 19 A -81 ) ALA( 19 A -80 ) GLN( 19 A -79 ) GLU( 19 A -78 ) THR( 19 A -77 ) ALA( 19 A -76 ) ALA( 19 A -75 ) LYS( 19 A -74 ) TRP( 19 A -73 ) PHE( 19 A -72 ) ARG( 19 A -71 ) GLY( 19 A -70 ) GLN( 19 A -69 ) ALA( 19 A -68 ) ASN( 19 A -67 ) LEU( 19 A -66 ) VAL( 19 A -65 ) LEU( 19 A -64 ) LEU( 19 A -63 ) ALA( 19 A -62 ) VAL( 19 A -61 ) GLU( 19 A -60 ) ALA( 19 A -59 ) GLU( 19 A -58 ) PRO( 19 A -57 ) LEU( 19 A -56 ) GLY( 19 A -55 ) GLU( 19 A -54 ) ASP( 19 A -53 ) LEU( 19 A -52 ) LYS( 19 A -51 ) TRP( 19 A -50 ) GLU( 19 A -49 ) ALA( 19 A -48 ) SER( 19 A -47 ) ARG( 19 A -46 ) GLY( 19 A -45 ) GLY( 19 A -44 ) ALA( 19 A -43 ) ARG( 19 A -42 ) PHE( 19 A -41 ) PRO( 19 A -40 ) HIS( 19 A -39 ) LEU( 19 A -38 ) TYR( 19 A -37 ) ARG( 19 A -36 ) PRO( 19 A -35 ) LEU( 19 A -34 ) LEU( 19 A -33 ) VAL( 19 A -32 ) SER( 19 A -31 ) GLU( 19 A -30 ) VAL( 19 A -29 ) THR( 19 A -28 ) ARG( 19 A -27 ) GLU( 19 A -26 ) ALA( 19 A -25 ) ASP( 19 A -24 ) LEU( 19 A -23 ) ASP( 19 A -22 ) LEU( 19 A -21 ) ASP( 19 A -20 ) ALA( 19 A -19 ) ASP( 19 A -18 ) GLY( 19 A -17 ) VAL( 19 A -16 ) PRO( 19 A -15 ) GLN( 19 A -14 ) LEU( 19 A -13 ) GLY( 19 A -12 ) ASP( 19 A -11 ) HIS( 19 A -10 ) LEU( 19 A -9 ) ALA( 19 A -8 ) LEU( 19 A -7 ) GLU( 19 A -6 ) HIS( 19 A -5 ) HIS( 19 A -4 ) HIS( 19 A -3 ) HIS( 19 A -2 ) HIS( 19 A -1 ) HIS( 19 A 0 ) MET( 20 A-121 ) THR( 20 A-120 ) LEU( 20 A-119 ) ILE( 20 A-118 ) TYR( 20 A-117 ) LYS( 20 A-116 ) ILE( 20 A-115 ) LEU( 20 A-114 ) SER( 20 A-113 ) ARG( 20 A-112 ) ALA( 20 A-111 ) GLU( 20 A-110 ) TRP( 20 A-109 ) ASP( 20 A-108 ) ALA( 20 A-107 ) ALA( 20 A-106 ) LYS( 20 A-105 ) ALA( 20 A-104 ) GLN( 20 A-103 ) GLY( 20 A-102 ) ARG( 20 A-101 ) PHE( 20 A-100 ) GLU( 20 A -99 ) GLY( 20 A -98 ) SER( 20 A -97 ) ALA( 20 A -96 ) VAL( 20 A -95 ) ASP( 20 A -94 ) LEU( 20 A -93 ) ALA( 20 A -92 ) ASP( 20 A -91 ) GLY( 20 A -90 ) PHE( 20 A -89 ) ILE( 20 A -88 ) HIS( 20 A -87 ) LEU( 20 A -86 ) SER( 20 A -85 ) ALA( 20 A -84 ) GLY( 20 A -83 ) GLU( 20 A -82 ) GLN( 20 A -81 ) ALA( 20 A -80 ) GLN( 20 A -79 ) GLU( 20 A -78 ) THR( 20 A -77 ) ALA( 20 A -76 ) ALA( 20 A -75 ) LYS( 20 A -74 ) TRP( 20 A -73 ) PHE( 20 A -72 ) ARG( 20 A -71 ) GLY( 20 A -70 ) GLN( 20 A -69 ) ALA( 20 A -68 ) ASN( 20 A -67 ) LEU( 20 A -66 ) VAL( 20 A -65 ) LEU( 20 A -64 ) LEU( 20 A -63 ) ALA( 20 A -62 ) VAL( 20 A -61 ) GLU( 20 A -60 ) ALA( 20 A -59 ) GLU( 20 A -58 ) PRO( 20 A -57 ) LEU( 20 A -56 ) GLY( 20 A -55 ) GLU( 20 A -54 ) ASP( 20 A -53 ) LEU( 20 A -52 ) LYS( 20 A -51 ) TRP( 20 A -50 ) GLU( 20 A -49 ) ALA( 20 A -48 ) SER( 20 A -47 ) ARG( 20 A -46 ) GLY( 20 A -45 ) GLY( 20 A -44 ) ALA( 20 A -43 ) ARG( 20 A -42 ) PHE( 20 A -41 ) PRO( 20 A -40 ) HIS( 20 A -39 ) LEU( 20 A -38 ) TYR( 20 A -37 ) ARG( 20 A -36 ) PRO( 20 A -35 ) LEU( 20 A -34 ) LEU( 20 A -33 ) VAL( 20 A -32 ) SER( 20 A -31 ) GLU( 20 A -30 ) VAL( 20 A -29 ) THR( 20 A -28 ) ARG( 20 A -27 ) GLU( 20 A -26 ) ALA( 20 A -25 ) ASP( 20 A -24 ) LEU( 20 A -23 ) ASP( 20 A -22 ) LEU( 20 A -21 ) ASP( 20 A -20 ) ALA( 20 A -19 ) ASP( 20 A -18 ) GLY( 20 A -17 ) VAL( 20 A -16 ) PRO( 20 A -15 ) GLN( 20 A -14 ) LEU( 20 A -13 ) GLY( 20 A -12 ) ASP( 20 A -11 ) HIS( 20 A -10 ) LEU( 20 A -9 ) ALA( 20 A -8 ) LEU( 20 A -7 ) GLU( 20 A -6 ) HIS( 20 A -5 ) HIS( 20 A -4 ) HIS( 20 A -3 ) HIS( 20 A -2 ) HIS( 20 A -1 ) HIS( 20 A 0 ) PDB Chain_ID: A 1 15 SEQRES: MET THR LEU ILE TYR LYS ILE LEU SER ARG ALA GLU TRP ASP ALA COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 16 30 SEQRES: ALA LYS ALA GLN GLY ARG PHE GLU GLY SER ALA VAL ASP LEU ALA COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 31 45 SEQRES: ASP GLY PHE ILE HIS LEU SER ALA GLY GLU GLN ALA GLN GLU THR COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 46 60 SEQRES: ALA ALA LYS TRP PHE ARG GLY GLN ALA ASN LEU VAL LEU LEU ALA COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 61 75 SEQRES: VAL GLU ALA GLU PRO LEU GLY GLU ASP LEU LYS TRP GLU ALA SER COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 76 90 SEQRES: ARG GLY GLY ALA ARG PHE PRO HIS LEU TYR ARG PRO LEU LEU VAL COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 91 105 SEQRES: SER GLU VAL THR ARG GLU ALA ASP LEU ASP LEU ASP ALA ASP GLY COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 106 120 SEQRES: VAL PRO GLN LEU GLY ASP HIS LEU ALA LEU GLU HIS HIS HIS HIS COORDS: ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 121 135 SEQRES: HIS HIS MET THR LEU ILE TYR LYS ILE LEU SER ARG ALA GLU TRP COORDS: ... ... MET THR LEU ILE TYR LYS ILE LEU SER ARG ALA GLU TRP 1 13 136 150 SEQRES: ASP ALA ALA LYS ALA GLN GLY ARG PHE GLU GLY SER ALA VAL ASP COORDS: ASP ALA ALA LYS ALA GLN GLY ARG PHE GLU GLY SER ALA VAL ASP 14 28 151 165 SEQRES: LEU ALA ASP GLY PHE ILE HIS LEU SER ALA GLY GLU GLN ALA GLN COORDS: LEU ALA ASP GLY PHE ILE HIS LEU SER ALA GLY GLU GLN ALA GLN 29 43 166 180 SEQRES: GLU THR ALA ALA LYS TRP PHE ARG GLY GLN ALA ASN LEU VAL LEU COORDS: GLU THR ALA ALA LYS TRP PHE ARG GLY GLN ALA ASN LEU VAL LEU 44 58 181 195 SEQRES: LEU ALA VAL GLU ALA GLU PRO LEU GLY GLU ASP LEU LYS TRP GLU COORDS: LEU ALA VAL GLU ALA GLU PRO LEU GLY GLU ASP LEU LYS TRP GLU 59 73 196 210 SEQRES: ALA SER ARG GLY GLY ALA ARG PHE PRO HIS LEU TYR ARG PRO LEU COORDS: ALA SER ARG GLY GLY ALA ARG PHE PRO HIS LEU TYR ARG PRO LEU 74 88 211 225 SEQRES: LEU VAL SER GLU VAL THR ARG GLU ALA ASP LEU ASP LEU ASP ALA COORDS: LEU VAL SER GLU VAL THR ARG GLU ALA ASP LEU ASP LEU ASP ALA 89 103 226 238 SEQRES: ASP GLY VAL PRO GLN LEU GLY ASP HIS LEU ALA LEU GLU COORDS: ASP GLY VAL PRO GLN LEU GLY ASP HIS LEU ALA LEU GLU 104 116 ==> The following residues have missing atoms: RES MOD#C SEQ ATOMS GLU( 1 A 12) HE2 ASP( 1 A 14) HD2 GLU( 1 A 23) HE2 ASP( 1 A 28) HD2 ASP( 1 A 31) HD2 GLU( 1 A 40) HE2 GLU( 1 A 44) HE2 GLU( 1 A 62) HE2 GLU( 1 A 64) HE2 GLU( 1 A 68) HE2 ASP( 1 A 69) HD2 GLU( 1 A 73) HE2 GLU( 1 A 92) HE2 GLU( 1 A 96) HE2 ASP( 1 A 98) HD2 ASP( 1 A 100) HD2 ASP( 1 A 102) HD2 ASP( 1 A 104) HD2 ASP( 1 A 111) HD2 GLU( 1 A 116) HE2 GLU( 2 A 12) HE2 ASP( 2 A 14) HD2 GLU( 2 A 23) HE2 ASP( 2 A 28) HD2 ASP( 2 A 31) HD2 GLU( 2 A 40) HE2 GLU( 2 A 44) HE2 GLU( 2 A 62) HE2 GLU( 2 A 64) HE2 GLU( 2 A 68) HE2 ASP( 2 A 69) HD2 GLU( 2 A 73) HE2 GLU( 2 A 92) HE2 GLU( 2 A 96) HE2 ASP( 2 A 98) HD2 ASP( 2 A 100) HD2 ASP( 2 A 102) HD2 ASP( 2 A 104) HD2 ASP( 2 A 111) HD2 GLU( 2 A 116) HE2 GLU( 3 A 12) HE2 ASP( 3 A 14) HD2 GLU( 3 A 23) HE2 ASP( 3 A 28) HD2 ASP( 3 A 31) HD2 GLU( 3 A 40) HE2 GLU( 3 A 44) HE2 GLU( 3 A 62) HE2 GLU( 3 A 64) HE2 GLU( 3 A 68) HE2 ASP( 3 A 69) HD2 GLU( 3 A 73) HE2 GLU( 3 A 92) HE2 GLU( 3 A 96) HE2 ASP( 3 A 98) HD2 ASP( 3 A 100) HD2 ASP( 3 A 102) HD2 ASP( 3 A 104) HD2 ASP( 3 A 111) HD2 GLU( 3 A 116) HE2 GLU( 4 A 12) HE2 ASP( 4 A 14) HD2 GLU( 4 A 23) HE2 ASP( 4 A 28) HD2 ASP( 4 A 31) HD2 GLU( 4 A 40) HE2 GLU( 4 A 44) HE2 GLU( 4 A 62) HE2 GLU( 4 A 64) HE2 GLU( 4 A 68) HE2 ASP( 4 A 69) HD2 GLU( 4 A 73) HE2 GLU( 4 A 92) HE2 GLU( 4 A 96) HE2 ASP( 4 A 98) HD2 ASP( 4 A 100) HD2 ASP( 4 A 102) HD2 ASP( 4 A 104) HD2 ASP( 4 A 111) HD2 GLU( 4 A 116) HE2 GLU( 5 A 12) HE2 ASP( 5 A 14) HD2 GLU( 5 A 23) HE2 ASP( 5 A 28) HD2 ASP( 5 A 31) HD2 GLU( 5 A 40) HE2 GLU( 5 A 44) HE2 GLU( 5 A 62) HE2 GLU( 5 A 64) HE2 GLU( 5 A 68) HE2 ASP( 5 A 69) HD2 GLU( 5 A 73) HE2 GLU( 5 A 92) HE2 GLU( 5 A 96) HE2 ASP( 5 A 98) HD2 ASP( 5 A 100) HD2 ASP( 5 A 102) HD2 ASP( 5 A 104) HD2 ASP( 5 A 111) HD2 GLU( 5 A 116) HE2 GLU( 6 A 12) HE2 ASP( 6 A 14) HD2 GLU( 6 A 23) HE2 ASP( 6 A 28) HD2 ASP( 6 A 31) HD2 GLU( 6 A 40) HE2 GLU( 6 A 44) HE2 GLU( 6 A 62) HE2 GLU( 6 A 64) HE2 GLU( 6 A 68) HE2 ASP( 6 A 69) HD2 GLU( 6 A 73) HE2 GLU( 6 A 92) HE2 GLU( 6 A 96) HE2 ASP( 6 A 98) HD2 ASP( 6 A 100) HD2 ASP( 6 A 102) HD2 ASP( 6 A 104) HD2 ASP( 6 A 111) HD2 GLU( 6 A 116) HE2 GLU( 7 A 12) HE2 ASP( 7 A 14) HD2 GLU( 7 A 23) HE2 ASP( 7 A 28) HD2 ASP( 7 A 31) HD2 GLU( 7 A 40) HE2 GLU( 7 A 44) HE2 GLU( 7 A 62) HE2 GLU( 7 A 64) HE2 GLU( 7 A 68) HE2 ASP( 7 A 69) HD2 GLU( 7 A 73) HE2 GLU( 7 A 92) HE2 GLU( 7 A 96) HE2 ASP( 7 A 98) HD2 ASP( 7 A 100) HD2 ASP( 7 A 102) HD2 ASP( 7 A 104) HD2 ASP( 7 A 111) HD2 GLU( 7 A 116) HE2 GLU( 8 A 12) HE2 ASP( 8 A 14) HD2 GLU( 8 A 23) HE2 ASP( 8 A 28) HD2 ASP( 8 A 31) HD2 GLU( 8 A 40) HE2 GLU( 8 A 44) HE2 GLU( 8 A 62) HE2 GLU( 8 A 64) HE2 GLU( 8 A 68) HE2 ASP( 8 A 69) HD2 GLU( 8 A 73) HE2 GLU( 8 A 92) HE2 GLU( 8 A 96) HE2 ASP( 8 A 98) HD2 ASP( 8 A 100) HD2 ASP( 8 A 102) HD2 ASP( 8 A 104) HD2 ASP( 8 A 111) HD2 GLU( 8 A 116) HE2 GLU( 9 A 12) HE2 ASP( 9 A 14) HD2 GLU( 9 A 23) HE2 ASP( 9 A 28) HD2 ASP( 9 A 31) HD2 GLU( 9 A 40) HE2 GLU( 9 A 44) HE2 GLU( 9 A 62) HE2 GLU( 9 A 64) HE2 GLU( 9 A 68) HE2 ASP( 9 A 69) HD2 GLU( 9 A 73) HE2 GLU( 9 A 92) HE2 GLU( 9 A 96) HE2 ASP( 9 A 98) HD2 ASP( 9 A 100) HD2 ASP( 9 A 102) HD2 ASP( 9 A 104) HD2 ASP( 9 A 111) HD2 GLU( 9 A 116) HE2 GLU( 10 A 12) HE2 ASP( 10 A 14) HD2 GLU( 10 A 23) HE2 ASP( 10 A 28) HD2 ASP( 10 A 31) HD2 GLU( 10 A 40) HE2 GLU( 10 A 44) HE2 GLU( 10 A 62) HE2 GLU( 10 A 64) HE2 GLU( 10 A 68) HE2 ASP( 10 A 69) HD2 GLU( 10 A 73) HE2 GLU( 10 A 92) HE2 GLU( 10 A 96) HE2 ASP( 10 A 98) HD2 ASP( 10 A 100) HD2 ASP( 10 A 102) HD2 ASP( 10 A 104) HD2 ASP( 10 A 111) HD2 GLU( 10 A 116) HE2 GLU( 11 A 12) HE2 ASP( 11 A 14) HD2 GLU( 11 A 23) HE2 ASP( 11 A 28) HD2 ASP( 11 A 31) HD2 GLU( 11 A 40) HE2 GLU( 11 A 44) HE2 GLU( 11 A 62) HE2 GLU( 11 A 64) HE2 GLU( 11 A 68) HE2 ASP( 11 A 69) HD2 GLU( 11 A 73) HE2 GLU( 11 A 92) HE2 GLU( 11 A 96) HE2 ASP( 11 A 98) HD2 ASP( 11 A 100) HD2 ASP( 11 A 102) HD2 ASP( 11 A 104) HD2 ASP( 11 A 111) HD2 GLU( 11 A 116) HE2 GLU( 12 A 12) HE2 ASP( 12 A 14) HD2 GLU( 12 A 23) HE2 ASP( 12 A 28) HD2 ASP( 12 A 31) HD2 GLU( 12 A 40) HE2 GLU( 12 A 44) HE2 GLU( 12 A 62) HE2 GLU( 12 A 64) HE2 GLU( 12 A 68) HE2 ASP( 12 A 69) HD2 GLU( 12 A 73) HE2 GLU( 12 A 92) HE2 GLU( 12 A 96) HE2 ASP( 12 A 98) HD2 ASP( 12 A 100) HD2 ASP( 12 A 102) HD2 ASP( 12 A 104) HD2 ASP( 12 A 111) HD2 GLU( 12 A 116) HE2 GLU( 13 A 12) HE2 ASP( 13 A 14) HD2 GLU( 13 A 23) HE2 ASP( 13 A 28) HD2 ASP( 13 A 31) HD2 GLU( 13 A 40) HE2 GLU( 13 A 44) HE2 GLU( 13 A 62) HE2 GLU( 13 A 64) HE2 GLU( 13 A 68) HE2 ASP( 13 A 69) HD2 GLU( 13 A 73) HE2 GLU( 13 A 92) HE2 GLU( 13 A 96) HE2 ASP( 13 A 98) HD2 ASP( 13 A 100) HD2 ASP( 13 A 102) HD2 ASP( 13 A 104) HD2 ASP( 13 A 111) HD2 GLU( 13 A 116) HE2 GLU( 14 A 12) HE2 ASP( 14 A 14) HD2 GLU( 14 A 23) HE2 ASP( 14 A 28) HD2 ASP( 14 A 31) HD2 GLU( 14 A 40) HE2 GLU( 14 A 44) HE2 GLU( 14 A 62) HE2 GLU( 14 A 64) HE2 GLU( 14 A 68) HE2 ASP( 14 A 69) HD2 GLU( 14 A 73) HE2 GLU( 14 A 92) HE2 GLU( 14 A 96) HE2 ASP( 14 A 98) HD2 ASP( 14 A 100) HD2 ASP( 14 A 102) HD2 ASP( 14 A 104) HD2 ASP( 14 A 111) HD2 GLU( 14 A 116) HE2 GLU( 15 A 12) HE2 ASP( 15 A 14) HD2 GLU( 15 A 23) HE2 ASP( 15 A 28) HD2 ASP( 15 A 31) HD2 GLU( 15 A 40) HE2 GLU( 15 A 44) HE2 GLU( 15 A 62) HE2 GLU( 15 A 64) HE2 GLU( 15 A 68) HE2 ASP( 15 A 69) HD2 GLU( 15 A 73) HE2 GLU( 15 A 92) HE2 GLU( 15 A 96) HE2 ASP( 15 A 98) HD2 ASP( 15 A 100) HD2 ASP( 15 A 102) HD2 ASP( 15 A 104) HD2 ASP( 15 A 111) HD2 GLU( 15 A 116) HE2 GLU( 16 A 12) HE2 ASP( 16 A 14) HD2 GLU( 16 A 23) HE2 ASP( 16 A 28) HD2 ASP( 16 A 31) HD2 GLU( 16 A 40) HE2 GLU( 16 A 44) HE2 GLU( 16 A 62) HE2 GLU( 16 A 64) HE2 GLU( 16 A 68) HE2 ASP( 16 A 69) HD2 GLU( 16 A 73) HE2 GLU( 16 A 92) HE2 GLU( 16 A 96) HE2 ASP( 16 A 98) HD2 ASP( 16 A 100) HD2 ASP( 16 A 102) HD2 ASP( 16 A 104) HD2 ASP( 16 A 111) HD2 GLU( 16 A 116) HE2 GLU( 17 A 12) HE2 ASP( 17 A 14) HD2 GLU( 17 A 23) HE2 ASP( 17 A 28) HD2 ASP( 17 A 31) HD2 GLU( 17 A 40) HE2 GLU( 17 A 44) HE2 GLU( 17 A 62) HE2 GLU( 17 A 64) HE2 GLU( 17 A 68) HE2 ASP( 17 A 69) HD2 GLU( 17 A 73) HE2 GLU( 17 A 92) HE2 GLU( 17 A 96) HE2 ASP( 17 A 98) HD2 ASP( 17 A 100) HD2 ASP( 17 A 102) HD2 ASP( 17 A 104) HD2 ASP( 17 A 111) HD2 GLU( 17 A 116) HE2 GLU( 18 A 12) HE2 ASP( 18 A 14) HD2 GLU( 18 A 23) HE2 ASP( 18 A 28) HD2 ASP( 18 A 31) HD2 GLU( 18 A 40) HE2 GLU( 18 A 44) HE2 GLU( 18 A 62) HE2 GLU( 18 A 64) HE2 GLU( 18 A 68) HE2 ASP( 18 A 69) HD2 GLU( 18 A 73) HE2 GLU( 18 A 92) HE2 GLU( 18 A 96) HE2 ASP( 18 A 98) HD2 ASP( 18 A 100) HD2 ASP( 18 A 102) HD2 ASP( 18 A 104) HD2 ASP( 18 A 111) HD2 GLU( 18 A 116) HE2 GLU( 19 A 12) HE2 ASP( 19 A 14) HD2 GLU( 19 A 23) HE2 ASP( 19 A 28) HD2 ASP( 19 A 31) HD2 GLU( 19 A 40) HE2 GLU( 19 A 44) HE2 GLU( 19 A 62) HE2 GLU( 19 A 64) HE2 GLU( 19 A 68) HE2 ASP( 19 A 69) HD2 GLU( 19 A 73) HE2 GLU( 19 A 92) HE2 GLU( 19 A 96) HE2 ASP( 19 A 98) HD2 ASP( 19 A 100) HD2 ASP( 19 A 102) HD2 ASP( 19 A 104) HD2 ASP( 19 A 111) HD2 GLU( 19 A 116) HE2 GLU( 20 A 12) HE2 ASP( 20 A 14) HD2 GLU( 20 A 23) HE2 ASP( 20 A 28) HD2 ASP( 20 A 31) HD2 GLU( 20 A 40) HE2 GLU( 20 A 44) HE2 GLU( 20 A 62) HE2 GLU( 20 A 64) HE2 GLU( 20 A 68) HE2 ASP( 20 A 69) HD2 GLU( 20 A 73) HE2 GLU( 20 A 92) HE2 GLU( 20 A 96) HE2 ASP( 20 A 98) HD2 ASP( 20 A 100) HD2 ASP( 20 A 102) HD2 ASP( 20 A 104) HD2 ASP( 20 A 111) HD2 GLU( 20 A 116) HE2 CHECK TERMINAL ATOMS -------------------- Terminal atom(s) showed in middle of sequence will be deleted: 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A 1H MET 1 A 2H MET 1 A 3H MET 1 A